Filgrastim therapy in a child with neutropenia induced by linezolid

We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast rec...

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Detalles Bibliográficos
Autores principales: Hernández Segurado, Marta, Arias Moya, Maria Ángeles, Gómez Pérez, Marta, Bonilla Porras, Macarena, Castillo Bazán, Eva, Bécares Martínez, Francisco Javier, Toledano Mayoral, Gema, Panadero Esteban, María Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724981/
https://www.ncbi.nlm.nih.gov/pubmed/23820894
http://dx.doi.org/10.1007/s11096-013-9814-8
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author Hernández Segurado, Marta
Arias Moya, Maria Ángeles
Gómez Pérez, Marta
Bonilla Porras, Macarena
Castillo Bazán, Eva
Bécares Martínez, Francisco Javier
Toledano Mayoral, Gema
Panadero Esteban, María Isabel
author_facet Hernández Segurado, Marta
Arias Moya, Maria Ángeles
Gómez Pérez, Marta
Bonilla Porras, Macarena
Castillo Bazán, Eva
Bécares Martínez, Francisco Javier
Toledano Mayoral, Gema
Panadero Esteban, María Isabel
author_sort Hernández Segurado, Marta
collection PubMed
description We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast recovery of the patient’s neutrophil-count. However, more experience with the off-label use of filgrastrim is needed in the pediatric population.
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spelling pubmed-37249812013-08-01 Filgrastim therapy in a child with neutropenia induced by linezolid Hernández Segurado, Marta Arias Moya, Maria Ángeles Gómez Pérez, Marta Bonilla Porras, Macarena Castillo Bazán, Eva Bécares Martínez, Francisco Javier Toledano Mayoral, Gema Panadero Esteban, María Isabel Int J Clin Pharm Case Report We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast recovery of the patient’s neutrophil-count. However, more experience with the off-label use of filgrastrim is needed in the pediatric population. Springer Netherlands 2013-07-03 2013 /pmc/articles/PMC3724981/ /pubmed/23820894 http://dx.doi.org/10.1007/s11096-013-9814-8 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Case Report
Hernández Segurado, Marta
Arias Moya, Maria Ángeles
Gómez Pérez, Marta
Bonilla Porras, Macarena
Castillo Bazán, Eva
Bécares Martínez, Francisco Javier
Toledano Mayoral, Gema
Panadero Esteban, María Isabel
Filgrastim therapy in a child with neutropenia induced by linezolid
title Filgrastim therapy in a child with neutropenia induced by linezolid
title_full Filgrastim therapy in a child with neutropenia induced by linezolid
title_fullStr Filgrastim therapy in a child with neutropenia induced by linezolid
title_full_unstemmed Filgrastim therapy in a child with neutropenia induced by linezolid
title_short Filgrastim therapy in a child with neutropenia induced by linezolid
title_sort filgrastim therapy in a child with neutropenia induced by linezolid
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724981/
https://www.ncbi.nlm.nih.gov/pubmed/23820894
http://dx.doi.org/10.1007/s11096-013-9814-8
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