Cargando…

TASK-2: a K(2P) K(+) channel with complex regulation and diverse physiological functions

TASK-2 (K(2P)5.1) is a two-pore domain K(+) channel belonging to the TALK subgroup of the K(2P) family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinization. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cid, L. Pablo, Roa-Rojas, Hugo A., Niemeyer, María I., González, Wendy, Araki, Masatake, Araki, Kimi, Sepúlveda, Francisco V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725403/ https://www.ncbi.nlm.nih.gov/pubmed/23908634 http://dx.doi.org/10.3389/fphys.2013.00198

Ejemplares similares

Pathophysiological significance of the two-pore domain K(+) channel K(2P)5.1 in splenic CD4(+)CD25(−) T cell subset from a chemically-induced murine inflammatory bowel disease model
por: Nakakura, Sawa, et al.
Publicado: (2015)

Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K(2P) background K(+) channel TASK-2
por: Niemeyer, María Isabel, et al.
Publicado: (2017)

KCNE Regulation of K(+) Channel Trafficking – a Sisyphean Task?
por: Kanda, Vikram A., et al.
Publicado: (2012)

Physiology and Pathophysiology of ClC-K/barttin Channels
por: Fahlke, Christoph, et al.
Publicado: (2010)

Tissue Distribution of Kir7.1 Inwardly Rectifying K(+) Channel Probed in a Knock-in Mouse Expressing a Haemagglutinin-Tagged Protein
por: Cornejo, Isabel, et al.
Publicado: (2018)

Asymmetric Interplay Between K(+) and Blocker and Atomistic Parameters From Physiological Experiments Quantify K(+) Channel Blocker Release
por: Gabriel, Tobias S., et al.
Publicado: (2021)

Understanding the Cap Structure in K2P Channels
por: Zúñiga, Leandro, et al.
Publicado: (2016)

Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9.1) channels and TASK‐1 (KCNK3, K2P3.1) channels
por: Cunningham, Kevin P., et al.
Publicado: (2019)

Gating of a pH-Sensitive K(2P) Potassium Channel by an Electrostatic Effect of Basic Sensor Residues on the Selectivity Filter
por: Zúñiga, Leandro, et al.
Publicado: (2011)

Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K(2)P Channels
por: Bustos, Daniel, et al.
Publicado: (2020)

Comparative analysis of right element mutant lox sites on recombination efficiency in embryonic stem cells
por: Araki, Kimi, et al.
Publicado: (2010)

Coronary Large Conductance Ca(2+)-Activated K(+) Channel Dysfunction in Diabetes Mellitus
por: Lu, Tong, et al.
Publicado: (2021)

K(+) channels and cell cycle progression in tumor cells
por: Ouadid-Ahidouch, Halima, et al.
Publicado: (2013)

The unusual stoichiometry of ADP activation of the K(ATP) channel
por: Hosy, Eric, et al.
Publicado: (2014)

Regions of KCNQ K(+) channels controlling functional expression
por: Choveau, Frank S., et al.
Publicado: (2012)

Mechanism of Regulation of Big-Conductance Ca(2+)-Activated K(+) Channels by mTOR Complex 2 in Podocytes
por: Wang, Yinhang, et al.
Publicado: (2019)

Tamoxifen feeding method is suitable for efficient conditional knockout
por: Yoshinobu, Kumiko, et al.
Publicado: (2020)

Managing Brain Extracellular K(+) during Neuronal Activity: The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms
por: Larsen, Brian Roland, et al.
Publicado: (2016)

Transcriptional Repression and Protein Degradation of the Ca(2+)-Activated K(+) Channel K(Ca)1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells
por: Khatun, Anowara, et al.
Publicado: (2018)

Functional effects of KCNQ K(+) channels in airway smooth muscle
por: Evseev, Alexey I., et al.
Publicado: (2013)

The Role of MicroRNAs in the Regulation of K(+) Channels in Epithelial Tissue
por: Pilmore, Elliot, et al.
Publicado: (2015)

The Role of K(v)7 Channels in Neural Plasticity and Behavior
por: Baculis, Brian C., et al.
Publicado: (2020)

Polyunsaturated Fatty Acids as Modulators of K(V)7 Channels
por: Larsson, Johan E., et al.
Publicado: (2020)

Specialized Functional Diversity and Interactions of the Na,K-ATPase
por: Matchkov, Vladimir V., et al.
Publicado: (2016)

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs
por: Shinoda, Saori, et al.
Publicado: (2019)

Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion Channel
por: Houtman, Marien J. C., et al.
Publicado: (2012)

Blockade of Acid-Sensing Ion Channels Increases Urinary Bladder Capacity With or Without Intravesical Irritation in Mice
por: Yoshiyama, Mitsuharu, et al.
Publicado: (2020)

Corrigendum: Blockade of Acid-Sensing Ion Channels Increases Urinary Bladder Capacity With or Without Intravesical Irritation in Mice
por: Yoshiyama, Mitsuharu, et al.
Publicado: (2020)

Disruption of Mbd5 in mice causes neuronal functional deficits and neurobehavioral abnormalities consistent with 2q23.1 microdeletion syndrome
por: Camarena, Vladimir, et al.
Publicado: (2014)

Regulation of myometrial contraction by ATP-sensitive potassium (K(ATP)) channel via activation of SUR2B and Kir 6.2 in mouse
por: HONG, Seung Hwa, et al.
Publicado: (2016)

The Effects of K(+) Channel Blockade on Eccentric and Isotonic Twitch and Fatiguing Contractions in situ
por: van Lunteren, Erik, et al.
Publicado: (2012)

Editorial: Ion Channels and Transporters in Ca(2+) -Dependent Functions of Lymphocytes
por: Hajdu, Peter, et al.
Publicado: (2022)

Physiological Responses and Bout Analysis in Elite Kickboxers During International K1 Competitions
por: Rydzik, Łukasz, et al.
Publicado: (2021)

K(V)7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells
por: Baldwin, Samuel N., et al.
Publicado: (2020)

Effects of exogenous hydrogen sulphide on calcium signalling, background (TASK) K channel activity and mitochondrial function in chemoreceptor cells
por: Buckler, Keith J.
Publicado: (2012)

The GPR55 agonist lysophosphatidylinositol directly activates intermediate-conductance Ca(2+)-activated K(+) channels
por: Bondarenko, Alexander I., et al.
Publicado: (2011)

PIST (GOPC) modulates the oncogenic voltage-gated potassium channel K(V)10.1
por: Herrmann, Solveig, et al.
Publicado: (2013)

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer
por: Comes, Núria, et al.
Publicado: (2013)

In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K(+) Channels; Interaction and New Targets
por: Moreno, Cristina, et al.
Publicado: (2016)

Aging Affects K(V)7 Channels and Perivascular Adipose Tissue-Mediated Vascular Tone
por: Wang, Yibin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1gqrqjlbo21rt77ajlh4la0905