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Lipocalin-2 is involved in emotional behaviors and cognitive function
Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard hou...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725407/ https://www.ncbi.nlm.nih.gov/pubmed/23908604 http://dx.doi.org/10.3389/fncel.2013.00122 |
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author | Ferreira, Ana C. Pinto, Vítor Dá Mesquita, Sandro Novais, Ashley Sousa, João C. Correia-Neves, Margarida Sousa, Nuno Palha, Joana A. Marques, Fernanda |
author_facet | Ferreira, Ana C. Pinto, Vítor Dá Mesquita, Sandro Novais, Ashley Sousa, João C. Correia-Neves, Margarida Sousa, Nuno Palha, Joana A. Marques, Fernanda |
author_sort | Ferreira, Ana C. |
collection | PubMed |
description | Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cognitive impairment in spatial learning tasks. These behavioral alterations were associated with a hyperactivation of the hypothalamic–pituitary–adrenal axis and with an altered brain cytoarchitecture in the hippocampus. More specifically, we found that the granular and pyramidal neurons of the ventral hippocampus, a region described to be associated with emotion, were hypertrophic, while neurons from the dorsal hippocampus, a region implicated in memory and cognition, were atrophic. In addition, LCN2-null mice presented synaptic impairment in hippocampal long-term potentiation. Whether the LCN2 effects are mediated through modulation of the level of corticosteroids or through a novel mechanism, the present observations bring further into light this immune-related protein as a player in the fine-tuning of behavior and of synaptic activity. |
format | Online Article Text |
id | pubmed-3725407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37254072013-08-01 Lipocalin-2 is involved in emotional behaviors and cognitive function Ferreira, Ana C. Pinto, Vítor Dá Mesquita, Sandro Novais, Ashley Sousa, João C. Correia-Neves, Margarida Sousa, Nuno Palha, Joana A. Marques, Fernanda Front Cell Neurosci Neuroscience Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cognitive impairment in spatial learning tasks. These behavioral alterations were associated with a hyperactivation of the hypothalamic–pituitary–adrenal axis and with an altered brain cytoarchitecture in the hippocampus. More specifically, we found that the granular and pyramidal neurons of the ventral hippocampus, a region described to be associated with emotion, were hypertrophic, while neurons from the dorsal hippocampus, a region implicated in memory and cognition, were atrophic. In addition, LCN2-null mice presented synaptic impairment in hippocampal long-term potentiation. Whether the LCN2 effects are mediated through modulation of the level of corticosteroids or through a novel mechanism, the present observations bring further into light this immune-related protein as a player in the fine-tuning of behavior and of synaptic activity. Frontiers Media S.A. 2013-07-29 /pmc/articles/PMC3725407/ /pubmed/23908604 http://dx.doi.org/10.3389/fncel.2013.00122 Text en Copyright © Ferreira, Pinto, Dá Mesquita, Novais, Sousa, Correia-Neves, Sousa, Palha and Marques. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Neuroscience Ferreira, Ana C. Pinto, Vítor Dá Mesquita, Sandro Novais, Ashley Sousa, João C. Correia-Neves, Margarida Sousa, Nuno Palha, Joana A. Marques, Fernanda Lipocalin-2 is involved in emotional behaviors and cognitive function |
title | Lipocalin-2 is involved in emotional behaviors and cognitive function |
title_full | Lipocalin-2 is involved in emotional behaviors and cognitive function |
title_fullStr | Lipocalin-2 is involved in emotional behaviors and cognitive function |
title_full_unstemmed | Lipocalin-2 is involved in emotional behaviors and cognitive function |
title_short | Lipocalin-2 is involved in emotional behaviors and cognitive function |
title_sort | lipocalin-2 is involved in emotional behaviors and cognitive function |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725407/ https://www.ncbi.nlm.nih.gov/pubmed/23908604 http://dx.doi.org/10.3389/fncel.2013.00122 |
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