Cargando…
Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology
Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in combination with prebiotics, (indigestible dietary fibre/carbohydrate), also confer a health benefit on the host via products resulting from anaerobic fermentation. There is a growing body of evidence doc...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725482/ https://www.ncbi.nlm.nih.gov/pubmed/23760057 http://dx.doi.org/10.3390/nu5061869 |
_version_ | 1782476798604345344 |
---|---|
author | Hardy, Holly Harris, Jennifer Lyon, Eleanor Beal, Jane Foey, Andrew D. |
author_facet | Hardy, Holly Harris, Jennifer Lyon, Eleanor Beal, Jane Foey, Andrew D. |
author_sort | Hardy, Holly |
collection | PubMed |
description | Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in combination with prebiotics, (indigestible dietary fibre/carbohydrate), also confer a health benefit on the host via products resulting from anaerobic fermentation. There is a growing body of evidence documenting the immune-modulatory ability of probiotic bacteria, it is therefore reasonable to suggest that this is potentiated via a combination of prebiotics and probiotics as a symbiotic mix. The need for probiotic formulations has been appreciated for the health benefits in “topping up your good bacteria” or indeed in an attempt to normalise the dysbiotic microbiota associated with immunopathology. This review will focus on the immunomodulatory role of probiotics and prebiotics on the cells, molecules and immune responses in the gut mucosae, from epithelial barrier to priming of adaptive responses by antigen presenting cells: immune fate decision—tolerance or activation? Modulation of normal homeostatic mechanisms, coupled with findings from probiotic and prebiotic delivery in pathological studies, will highlight the role for these xenobiotics in dysbiosis associated with immunopathology in the context of inflammatory bowel disease, colorectal cancer and hypersensitivity. |
format | Online Article Text |
id | pubmed-3725482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37254822013-07-29 Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology Hardy, Holly Harris, Jennifer Lyon, Eleanor Beal, Jane Foey, Andrew D. Nutrients Review Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in combination with prebiotics, (indigestible dietary fibre/carbohydrate), also confer a health benefit on the host via products resulting from anaerobic fermentation. There is a growing body of evidence documenting the immune-modulatory ability of probiotic bacteria, it is therefore reasonable to suggest that this is potentiated via a combination of prebiotics and probiotics as a symbiotic mix. The need for probiotic formulations has been appreciated for the health benefits in “topping up your good bacteria” or indeed in an attempt to normalise the dysbiotic microbiota associated with immunopathology. This review will focus on the immunomodulatory role of probiotics and prebiotics on the cells, molecules and immune responses in the gut mucosae, from epithelial barrier to priming of adaptive responses by antigen presenting cells: immune fate decision—tolerance or activation? Modulation of normal homeostatic mechanisms, coupled with findings from probiotic and prebiotic delivery in pathological studies, will highlight the role for these xenobiotics in dysbiosis associated with immunopathology in the context of inflammatory bowel disease, colorectal cancer and hypersensitivity. MDPI 2013-05-29 /pmc/articles/PMC3725482/ /pubmed/23760057 http://dx.doi.org/10.3390/nu5061869 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Hardy, Holly Harris, Jennifer Lyon, Eleanor Beal, Jane Foey, Andrew D. Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology |
title | Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology |
title_full | Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology |
title_fullStr | Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology |
title_full_unstemmed | Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology |
title_short | Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology |
title_sort | probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725482/ https://www.ncbi.nlm.nih.gov/pubmed/23760057 http://dx.doi.org/10.3390/nu5061869 |
work_keys_str_mv | AT hardyholly probioticsprebioticsandimmunomodulationofgutmucosaldefenceshomeostasisandimmunopathology AT harrisjennifer probioticsprebioticsandimmunomodulationofgutmucosaldefenceshomeostasisandimmunopathology AT lyoneleanor probioticsprebioticsandimmunomodulationofgutmucosaldefenceshomeostasisandimmunopathology AT bealjane probioticsprebioticsandimmunomodulationofgutmucosaldefenceshomeostasisandimmunopathology AT foeyandrewd probioticsprebioticsandimmunomodulationofgutmucosaldefenceshomeostasisandimmunopathology |