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Binding of disordered proteins to a protein hub

A small number of proteins, called hubs, have high connectivity and are essential for interactome functionality and integrity. Keap1 is a crucial hub in the oxidative stress response and apoptosis. The Kelch domain of Keap1 preferentially binds to disordered regions of its partners, which share simi...

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Detalles Bibliográficos
Autores principales: Cino, Elio A., Killoran, Ryan C., Karttunen, Mikko, Choy, Wing-Yiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725505/
https://www.ncbi.nlm.nih.gov/pubmed/23892546
http://dx.doi.org/10.1038/srep02305

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