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Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy
Today, researchers are constantly developing new nanomaterials, nanodevices, and nanoparticles to meet unmet needs in the delivery of therapeutic agents and imaging agents for cancer therapy and diagnosis, respectively. Of particular interest here are lipid-based nanoparticles (LNPs) that are genuin...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725835/ https://www.ncbi.nlm.nih.gov/pubmed/23936655 http://dx.doi.org/10.1155/2013/165981 |
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author | Miller, Andrew D. |
author_facet | Miller, Andrew D. |
author_sort | Miller, Andrew D. |
collection | PubMed |
description | Today, researchers are constantly developing new nanomaterials, nanodevices, and nanoparticles to meet unmet needs in the delivery of therapeutic agents and imaging agents for cancer therapy and diagnosis, respectively. Of particular interest here are lipid-based nanoparticles (LNPs) that are genuine particles (approximately 100 nm in dimension) assembled from varieties of lipid and other chemical components that act collectively to overcome biological barriers (biobarriers), in order for LNPs to preferentially accumulate in or around disease-target cells for the functional delivery of therapeutic agents for treatment or of imaging agents for diagnosis. The capabilities of these LNPs will clearly vary depending on functional requirements, but the nanoscale allows for an impressive level of diversity in capabilities to enable corresponding LNPs to address an equally diverse range of functional requirements. Accordingly, LNPs should be considered appropriate vehicles to provide an integrated, personalized approach to cancer diagnosis and therapy in future cancer disease management. |
format | Online Article Text |
id | pubmed-3725835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37258352013-08-09 Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy Miller, Andrew D. J Drug Deliv Review Article Today, researchers are constantly developing new nanomaterials, nanodevices, and nanoparticles to meet unmet needs in the delivery of therapeutic agents and imaging agents for cancer therapy and diagnosis, respectively. Of particular interest here are lipid-based nanoparticles (LNPs) that are genuine particles (approximately 100 nm in dimension) assembled from varieties of lipid and other chemical components that act collectively to overcome biological barriers (biobarriers), in order for LNPs to preferentially accumulate in or around disease-target cells for the functional delivery of therapeutic agents for treatment or of imaging agents for diagnosis. The capabilities of these LNPs will clearly vary depending on functional requirements, but the nanoscale allows for an impressive level of diversity in capabilities to enable corresponding LNPs to address an equally diverse range of functional requirements. Accordingly, LNPs should be considered appropriate vehicles to provide an integrated, personalized approach to cancer diagnosis and therapy in future cancer disease management. Hindawi Publishing Corporation 2013 2013-07-09 /pmc/articles/PMC3725835/ /pubmed/23936655 http://dx.doi.org/10.1155/2013/165981 Text en Copyright © 2013 Andrew D. Miller. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Miller, Andrew D. Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy |
title | Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy |
title_full | Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy |
title_fullStr | Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy |
title_full_unstemmed | Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy |
title_short | Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy |
title_sort | lipid-based nanoparticles in cancer diagnosis and therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725835/ https://www.ncbi.nlm.nih.gov/pubmed/23936655 http://dx.doi.org/10.1155/2013/165981 |
work_keys_str_mv | AT millerandrewd lipidbasednanoparticlesincancerdiagnosisandtherapy |