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Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy

Today, researchers are constantly developing new nanomaterials, nanodevices, and nanoparticles to meet unmet needs in the delivery of therapeutic agents and imaging agents for cancer therapy and diagnosis, respectively. Of particular interest here are lipid-based nanoparticles (LNPs) that are genuin...

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Detalles Bibliográficos
Autor principal: Miller, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725835/
https://www.ncbi.nlm.nih.gov/pubmed/23936655
http://dx.doi.org/10.1155/2013/165981
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author Miller, Andrew D.
author_facet Miller, Andrew D.
author_sort Miller, Andrew D.
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description Today, researchers are constantly developing new nanomaterials, nanodevices, and nanoparticles to meet unmet needs in the delivery of therapeutic agents and imaging agents for cancer therapy and diagnosis, respectively. Of particular interest here are lipid-based nanoparticles (LNPs) that are genuine particles (approximately 100 nm in dimension) assembled from varieties of lipid and other chemical components that act collectively to overcome biological barriers (biobarriers), in order for LNPs to preferentially accumulate in or around disease-target cells for the functional delivery of therapeutic agents for treatment or of imaging agents for diagnosis. The capabilities of these LNPs will clearly vary depending on functional requirements, but the nanoscale allows for an impressive level of diversity in capabilities to enable corresponding LNPs to address an equally diverse range of functional requirements. Accordingly, LNPs should be considered appropriate vehicles to provide an integrated, personalized approach to cancer diagnosis and therapy in future cancer disease management.
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spelling pubmed-37258352013-08-09 Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy Miller, Andrew D. J Drug Deliv Review Article Today, researchers are constantly developing new nanomaterials, nanodevices, and nanoparticles to meet unmet needs in the delivery of therapeutic agents and imaging agents for cancer therapy and diagnosis, respectively. Of particular interest here are lipid-based nanoparticles (LNPs) that are genuine particles (approximately 100 nm in dimension) assembled from varieties of lipid and other chemical components that act collectively to overcome biological barriers (biobarriers), in order for LNPs to preferentially accumulate in or around disease-target cells for the functional delivery of therapeutic agents for treatment or of imaging agents for diagnosis. The capabilities of these LNPs will clearly vary depending on functional requirements, but the nanoscale allows for an impressive level of diversity in capabilities to enable corresponding LNPs to address an equally diverse range of functional requirements. Accordingly, LNPs should be considered appropriate vehicles to provide an integrated, personalized approach to cancer diagnosis and therapy in future cancer disease management. Hindawi Publishing Corporation 2013 2013-07-09 /pmc/articles/PMC3725835/ /pubmed/23936655 http://dx.doi.org/10.1155/2013/165981 Text en Copyright © 2013 Andrew D. Miller. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Miller, Andrew D.
Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy
title Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy
title_full Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy
title_fullStr Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy
title_full_unstemmed Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy
title_short Lipid-Based Nanoparticles in Cancer Diagnosis and Therapy
title_sort lipid-based nanoparticles in cancer diagnosis and therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725835/
https://www.ncbi.nlm.nih.gov/pubmed/23936655
http://dx.doi.org/10.1155/2013/165981
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