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Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium

Previous studies have shown that acute exercise preconditions the myocardium from ischemic injury. The purpose of this study was to test whether acute exercise protects the hypertensive myocardium from ischemia-induced diastolic rigor, and to compare the response between normotensive and uncompensat...

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Detalles Bibliográficos
Autores principales: Reger, Patricia O, Kolwicz, Stephen C, Libonati, Joseph R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725917/
https://www.ncbi.nlm.nih.gov/pubmed/23961371
http://dx.doi.org/10.1186/2193-1801-1-46
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author Reger, Patricia O
Kolwicz, Stephen C
Libonati, Joseph R
author_facet Reger, Patricia O
Kolwicz, Stephen C
Libonati, Joseph R
author_sort Reger, Patricia O
collection PubMed
description Previous studies have shown that acute exercise preconditions the myocardium from ischemic injury. The purpose of this study was to test whether acute exercise protects the hypertensive myocardium from ischemia-induced diastolic rigor, and to compare the response between normotensive and uncompensated hypertensive hearts. Hearts harvested from female Wistar-Kyoto (WKY; n = 24) and spontaneously hypertensive rats (SHR; n = 27) (age:10–12 weeks) were exposed to ischemia (Langendorff isovolumic preparation; 22 minutes of no flow ischemia and studied following prior conditions of: 1) no exercise (WKY-CON, n=8; SHR-CON, n=8); 2) ischemia initiated one hour post-acute exercise (WKY-1HR, n = 8; SHR-1HR, n = 11); and 3) ischemia initiated 24 hours post-acute exercise (WKY-24HR; n = 8; SHR-24HR, n = 8). Acute exercise consisted of one bout of treadmill running at 25 m/min for 60 minutes. Heart weight was similar between WKY and SHR despite elevated in vivo resting systolic blood pressure and rate pressure product in SHR (P<0.05). During normoxic perfusion, left ventricular (LV) Langendorff performance was similar between WKY and SHR over the post-exercise time course. However, during ischemia, LV diastolic rigor was less in WKY vs. SHR (P<0.05). Acute exercise augmented ischemia-induced LV dysfunction one hour post-exercise in SHR (P<0.05), with gradual recovery by 24 hours post-exercise. These data suggest that acute exercise promotes ischemic diastolic rigor in SHR, even prior to the development of cardiac hypertrophy.
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spelling pubmed-37259172013-07-30 Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium Reger, Patricia O Kolwicz, Stephen C Libonati, Joseph R Springerplus Research Previous studies have shown that acute exercise preconditions the myocardium from ischemic injury. The purpose of this study was to test whether acute exercise protects the hypertensive myocardium from ischemia-induced diastolic rigor, and to compare the response between normotensive and uncompensated hypertensive hearts. Hearts harvested from female Wistar-Kyoto (WKY; n = 24) and spontaneously hypertensive rats (SHR; n = 27) (age:10–12 weeks) were exposed to ischemia (Langendorff isovolumic preparation; 22 minutes of no flow ischemia and studied following prior conditions of: 1) no exercise (WKY-CON, n=8; SHR-CON, n=8); 2) ischemia initiated one hour post-acute exercise (WKY-1HR, n = 8; SHR-1HR, n = 11); and 3) ischemia initiated 24 hours post-acute exercise (WKY-24HR; n = 8; SHR-24HR, n = 8). Acute exercise consisted of one bout of treadmill running at 25 m/min for 60 minutes. Heart weight was similar between WKY and SHR despite elevated in vivo resting systolic blood pressure and rate pressure product in SHR (P<0.05). During normoxic perfusion, left ventricular (LV) Langendorff performance was similar between WKY and SHR over the post-exercise time course. However, during ischemia, LV diastolic rigor was less in WKY vs. SHR (P<0.05). Acute exercise augmented ischemia-induced LV dysfunction one hour post-exercise in SHR (P<0.05), with gradual recovery by 24 hours post-exercise. These data suggest that acute exercise promotes ischemic diastolic rigor in SHR, even prior to the development of cardiac hypertrophy. Springer International Publishing AG 2012-11-02 /pmc/articles/PMC3725917/ /pubmed/23961371 http://dx.doi.org/10.1186/2193-1801-1-46 Text en © Reger et al.; licensee Springer. 2012 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Reger, Patricia O
Kolwicz, Stephen C
Libonati, Joseph R
Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium
title Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium
title_full Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium
title_fullStr Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium
title_full_unstemmed Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium
title_short Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium
title_sort acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725917/
https://www.ncbi.nlm.nih.gov/pubmed/23961371
http://dx.doi.org/10.1186/2193-1801-1-46
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