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The Interplay between the Bone and the Immune System

In the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and mye...

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Autores principales: Mori, Giorgio, D'Amelio, Patrizia, Faccio, Roberta, Brunetti, Giacomina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725924/
https://www.ncbi.nlm.nih.gov/pubmed/23935650
http://dx.doi.org/10.1155/2013/720504
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author Mori, Giorgio
D'Amelio, Patrizia
Faccio, Roberta
Brunetti, Giacomina
author_facet Mori, Giorgio
D'Amelio, Patrizia
Faccio, Roberta
Brunetti, Giacomina
author_sort Mori, Giorgio
collection PubMed
description In the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and myeloid dendritic cells. On the other hand, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived. Furthermore, many of the soluble mediators of immune cells, including cytokines and growth factors, regulate the activities of osteoblasts and osteoclasts. This increased recognition of the complex interactions between the immune system and bone led to the development of the interdisciplinary osteoimmunology field. Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies. In these review, we reported the latest findings about the reciprocal regulation of bone and immune cells.
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spelling pubmed-37259242013-08-09 The Interplay between the Bone and the Immune System Mori, Giorgio D'Amelio, Patrizia Faccio, Roberta Brunetti, Giacomina Clin Dev Immunol Review Article In the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and myeloid dendritic cells. On the other hand, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived. Furthermore, many of the soluble mediators of immune cells, including cytokines and growth factors, regulate the activities of osteoblasts and osteoclasts. This increased recognition of the complex interactions between the immune system and bone led to the development of the interdisciplinary osteoimmunology field. Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies. In these review, we reported the latest findings about the reciprocal regulation of bone and immune cells. Hindawi Publishing Corporation 2013 2013-07-14 /pmc/articles/PMC3725924/ /pubmed/23935650 http://dx.doi.org/10.1155/2013/720504 Text en Copyright © 2013 Giorgio Mori et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mori, Giorgio
D'Amelio, Patrizia
Faccio, Roberta
Brunetti, Giacomina
The Interplay between the Bone and the Immune System
title The Interplay between the Bone and the Immune System
title_full The Interplay between the Bone and the Immune System
title_fullStr The Interplay between the Bone and the Immune System
title_full_unstemmed The Interplay between the Bone and the Immune System
title_short The Interplay between the Bone and the Immune System
title_sort interplay between the bone and the immune system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725924/
https://www.ncbi.nlm.nih.gov/pubmed/23935650
http://dx.doi.org/10.1155/2013/720504
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