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Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli

Background and Purpose: Tandem acute thrombotic emboli in the cervical and intracranial arteries are an unusual cause of stroke presenting unique management challenges. In regional systems of acute stroke care anchored by Comprehensive Stroke Centers (CSC), combined fibrinolytic, endovascular, and o...

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Autores principales: Hinman, Jason D., Rao, Neal M., Yallapragada, Anil, Capri, Joe, Souda, Puneet, Whitelegge, Julian, Yong, William H., Jahan, Reza, Quinones-Baldrich, William, Saver, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725951/
https://www.ncbi.nlm.nih.gov/pubmed/23908644
http://dx.doi.org/10.3389/fneur.2013.00104
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author Hinman, Jason D.
Rao, Neal M.
Yallapragada, Anil
Capri, Joe
Souda, Puneet
Whitelegge, Julian
Yong, William H.
Jahan, Reza
Quinones-Baldrich, William
Saver, Jeffrey L.
author_facet Hinman, Jason D.
Rao, Neal M.
Yallapragada, Anil
Capri, Joe
Souda, Puneet
Whitelegge, Julian
Yong, William H.
Jahan, Reza
Quinones-Baldrich, William
Saver, Jeffrey L.
author_sort Hinman, Jason D.
collection PubMed
description Background and Purpose: Tandem acute thrombotic emboli in the cervical and intracranial arteries are an unusual cause of stroke presenting unique management challenges. In regional systems of acute stroke care anchored by Comprehensive Stroke Centers (CSC), combined fibrinolytic, endovascular, and open surgical intervention is a new therapeutic option. Summary of Case: A 28-year-old male underwent retinal surgery, including post-operative neck compression and the next day presented to a primary stroke center with aphasia and right hemiplegia. Intravenous tissue plasminogen activator therapy was initiated and the patient was transferred to a CSC for higher level of care (drip and ship). Imaging at the CSC demonstrated tandem thrombi: a near occlusive lesion at the origin of the left cervical internal carotid artery and a total occlusion of the M1 segment of the left middle cerebral artery. Endovascular thrombectomy with the Solitaire stent retriever resulted in intracranial recanalization (grip). Immediately after the endovascular procedure, open carotid thrombectomy was performed to achieve cervical carotid revascularization without systemic heparinization (slice). Both cervical carotid and intracranial thrombi were processed for proteomic analysis via mass spectrometry (dice). Conclusion: Combined fibrinolytic, endovascular, and open surgical intervention can yield revascularization and good clinical outcome in cases of tandem lesions.
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spelling pubmed-37259512013-08-01 Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli Hinman, Jason D. Rao, Neal M. Yallapragada, Anil Capri, Joe Souda, Puneet Whitelegge, Julian Yong, William H. Jahan, Reza Quinones-Baldrich, William Saver, Jeffrey L. Front Neurol Neuroscience Background and Purpose: Tandem acute thrombotic emboli in the cervical and intracranial arteries are an unusual cause of stroke presenting unique management challenges. In regional systems of acute stroke care anchored by Comprehensive Stroke Centers (CSC), combined fibrinolytic, endovascular, and open surgical intervention is a new therapeutic option. Summary of Case: A 28-year-old male underwent retinal surgery, including post-operative neck compression and the next day presented to a primary stroke center with aphasia and right hemiplegia. Intravenous tissue plasminogen activator therapy was initiated and the patient was transferred to a CSC for higher level of care (drip and ship). Imaging at the CSC demonstrated tandem thrombi: a near occlusive lesion at the origin of the left cervical internal carotid artery and a total occlusion of the M1 segment of the left middle cerebral artery. Endovascular thrombectomy with the Solitaire stent retriever resulted in intracranial recanalization (grip). Immediately after the endovascular procedure, open carotid thrombectomy was performed to achieve cervical carotid revascularization without systemic heparinization (slice). Both cervical carotid and intracranial thrombi were processed for proteomic analysis via mass spectrometry (dice). Conclusion: Combined fibrinolytic, endovascular, and open surgical intervention can yield revascularization and good clinical outcome in cases of tandem lesions. Frontiers Media S.A. 2013-07-29 /pmc/articles/PMC3725951/ /pubmed/23908644 http://dx.doi.org/10.3389/fneur.2013.00104 Text en Copyright © 2013 Hinman, Rao, Yallapragada, Capri, Souda, Whitelegge, Yong, Jahan, Quinones-Baldrich and Saver. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Hinman, Jason D.
Rao, Neal M.
Yallapragada, Anil
Capri, Joe
Souda, Puneet
Whitelegge, Julian
Yong, William H.
Jahan, Reza
Quinones-Baldrich, William
Saver, Jeffrey L.
Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli
title Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli
title_full Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli
title_fullStr Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli
title_full_unstemmed Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli
title_short Drip, Ship, and Grip, then Slice and Dice: Comprehensive Stroke Center Management of Cervical and Intracranial Emboli
title_sort drip, ship, and grip, then slice and dice: comprehensive stroke center management of cervical and intracranial emboli
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725951/
https://www.ncbi.nlm.nih.gov/pubmed/23908644
http://dx.doi.org/10.3389/fneur.2013.00104
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