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The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period

BACKGROUND: Inflammatory bowel disease (IBD)-indeterminate is a subgroup of IBD that has features of both ulcerative colitis (UC) and Crohn’s disease (CD). AIMS: To determine the clinical course of IBD-indeterminate in children over a 25 year period. METHODS: We performed a retrospective investigati...

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Autores principales: Malaty, Hoda M, Mehta, Seema, Abraham, Bincy, Garnett, Elizabeth A, Ferry, George D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726299/
https://www.ncbi.nlm.nih.gov/pubmed/23901288
http://dx.doi.org/10.2147/CEG.S44700
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author Malaty, Hoda M
Mehta, Seema
Abraham, Bincy
Garnett, Elizabeth A
Ferry, George D
author_facet Malaty, Hoda M
Mehta, Seema
Abraham, Bincy
Garnett, Elizabeth A
Ferry, George D
author_sort Malaty, Hoda M
collection PubMed
description BACKGROUND: Inflammatory bowel disease (IBD)-indeterminate is a subgroup of IBD that has features of both ulcerative colitis (UC) and Crohn’s disease (CD). AIMS: To determine the clinical course of IBD-indeterminate in children over a 25 year period. METHODS: We performed a retrospective investigation on children diagnosed with IBD. Diagnosis and disease distribution of IBD was based on clinical, radiologic, endoscopic, and histologic examinations. RESULTS: Four hundred and twenty children diagnosed with IBD between 1986 and 2003 were identified from the IBD registry, 78 (22%) of whom were diagnosed with IBD-indeterminate. The mean age at diagnosis was 9.2 ± 4 years and the mean follow-up period was 4.1 ± 2 years. In 2003, 18 of 78 children (23%) were reclassified by the same physician based on the endoscopic and pathologic findings as follows: eight children with CD, five children with UC, and five children with non-IBD (eg, eosinophilic colitis). During 2011, 20 of the 60 patients who had maintained an IBD-indeterminate diagnosis were located and contacted, and detailed telephone interviews were conducted by the corresponding author. Two patients were reclassified as having CD (10%), one patient was reclassified as having eosinophilic colitis (5%), six patients remained with IBD-indeterminate (30%), and eleven patients (55%) reported a complete resolution of their symptoms. The follow-up period ranged from 10–18 years (mean 12.5 ± 3 years). Children who were reclassified as having CD were significantly younger than those who maintained an IBD-indeterminate diagnosis (6.4 ± 4 years versus11.2 ± 3 years, respectively, P = 0.05). CONCLUSION: Children with IBD-indeterminate remain classified as IBD-indeterminate, or were clinically reclassified as CD or non-IBD, or became asymptomatic as they transitioned into adulthood. The need for IBD-indeterminate classification is of importance, especially when deciding on management and treatment.
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spelling pubmed-37262992013-07-30 The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period Malaty, Hoda M Mehta, Seema Abraham, Bincy Garnett, Elizabeth A Ferry, George D Clin Exp Gastroenterol Original Research BACKGROUND: Inflammatory bowel disease (IBD)-indeterminate is a subgroup of IBD that has features of both ulcerative colitis (UC) and Crohn’s disease (CD). AIMS: To determine the clinical course of IBD-indeterminate in children over a 25 year period. METHODS: We performed a retrospective investigation on children diagnosed with IBD. Diagnosis and disease distribution of IBD was based on clinical, radiologic, endoscopic, and histologic examinations. RESULTS: Four hundred and twenty children diagnosed with IBD between 1986 and 2003 were identified from the IBD registry, 78 (22%) of whom were diagnosed with IBD-indeterminate. The mean age at diagnosis was 9.2 ± 4 years and the mean follow-up period was 4.1 ± 2 years. In 2003, 18 of 78 children (23%) were reclassified by the same physician based on the endoscopic and pathologic findings as follows: eight children with CD, five children with UC, and five children with non-IBD (eg, eosinophilic colitis). During 2011, 20 of the 60 patients who had maintained an IBD-indeterminate diagnosis were located and contacted, and detailed telephone interviews were conducted by the corresponding author. Two patients were reclassified as having CD (10%), one patient was reclassified as having eosinophilic colitis (5%), six patients remained with IBD-indeterminate (30%), and eleven patients (55%) reported a complete resolution of their symptoms. The follow-up period ranged from 10–18 years (mean 12.5 ± 3 years). Children who were reclassified as having CD were significantly younger than those who maintained an IBD-indeterminate diagnosis (6.4 ± 4 years versus11.2 ± 3 years, respectively, P = 0.05). CONCLUSION: Children with IBD-indeterminate remain classified as IBD-indeterminate, or were clinically reclassified as CD or non-IBD, or became asymptomatic as they transitioned into adulthood. The need for IBD-indeterminate classification is of importance, especially when deciding on management and treatment. Dove Medical Press 2013-07-23 /pmc/articles/PMC3726299/ /pubmed/23901288 http://dx.doi.org/10.2147/CEG.S44700 Text en © 2013 Malaty et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Malaty, Hoda M
Mehta, Seema
Abraham, Bincy
Garnett, Elizabeth A
Ferry, George D
The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period
title The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period
title_full The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period
title_fullStr The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period
title_full_unstemmed The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period
title_short The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period
title_sort natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726299/
https://www.ncbi.nlm.nih.gov/pubmed/23901288
http://dx.doi.org/10.2147/CEG.S44700
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