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The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period
BACKGROUND: Inflammatory bowel disease (IBD)-indeterminate is a subgroup of IBD that has features of both ulcerative colitis (UC) and Crohn’s disease (CD). AIMS: To determine the clinical course of IBD-indeterminate in children over a 25 year period. METHODS: We performed a retrospective investigati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726299/ https://www.ncbi.nlm.nih.gov/pubmed/23901288 http://dx.doi.org/10.2147/CEG.S44700 |
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author | Malaty, Hoda M Mehta, Seema Abraham, Bincy Garnett, Elizabeth A Ferry, George D |
author_facet | Malaty, Hoda M Mehta, Seema Abraham, Bincy Garnett, Elizabeth A Ferry, George D |
author_sort | Malaty, Hoda M |
collection | PubMed |
description | BACKGROUND: Inflammatory bowel disease (IBD)-indeterminate is a subgroup of IBD that has features of both ulcerative colitis (UC) and Crohn’s disease (CD). AIMS: To determine the clinical course of IBD-indeterminate in children over a 25 year period. METHODS: We performed a retrospective investigation on children diagnosed with IBD. Diagnosis and disease distribution of IBD was based on clinical, radiologic, endoscopic, and histologic examinations. RESULTS: Four hundred and twenty children diagnosed with IBD between 1986 and 2003 were identified from the IBD registry, 78 (22%) of whom were diagnosed with IBD-indeterminate. The mean age at diagnosis was 9.2 ± 4 years and the mean follow-up period was 4.1 ± 2 years. In 2003, 18 of 78 children (23%) were reclassified by the same physician based on the endoscopic and pathologic findings as follows: eight children with CD, five children with UC, and five children with non-IBD (eg, eosinophilic colitis). During 2011, 20 of the 60 patients who had maintained an IBD-indeterminate diagnosis were located and contacted, and detailed telephone interviews were conducted by the corresponding author. Two patients were reclassified as having CD (10%), one patient was reclassified as having eosinophilic colitis (5%), six patients remained with IBD-indeterminate (30%), and eleven patients (55%) reported a complete resolution of their symptoms. The follow-up period ranged from 10–18 years (mean 12.5 ± 3 years). Children who were reclassified as having CD were significantly younger than those who maintained an IBD-indeterminate diagnosis (6.4 ± 4 years versus11.2 ± 3 years, respectively, P = 0.05). CONCLUSION: Children with IBD-indeterminate remain classified as IBD-indeterminate, or were clinically reclassified as CD or non-IBD, or became asymptomatic as they transitioned into adulthood. The need for IBD-indeterminate classification is of importance, especially when deciding on management and treatment. |
format | Online Article Text |
id | pubmed-3726299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-37262992013-07-30 The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period Malaty, Hoda M Mehta, Seema Abraham, Bincy Garnett, Elizabeth A Ferry, George D Clin Exp Gastroenterol Original Research BACKGROUND: Inflammatory bowel disease (IBD)-indeterminate is a subgroup of IBD that has features of both ulcerative colitis (UC) and Crohn’s disease (CD). AIMS: To determine the clinical course of IBD-indeterminate in children over a 25 year period. METHODS: We performed a retrospective investigation on children diagnosed with IBD. Diagnosis and disease distribution of IBD was based on clinical, radiologic, endoscopic, and histologic examinations. RESULTS: Four hundred and twenty children diagnosed with IBD between 1986 and 2003 were identified from the IBD registry, 78 (22%) of whom were diagnosed with IBD-indeterminate. The mean age at diagnosis was 9.2 ± 4 years and the mean follow-up period was 4.1 ± 2 years. In 2003, 18 of 78 children (23%) were reclassified by the same physician based on the endoscopic and pathologic findings as follows: eight children with CD, five children with UC, and five children with non-IBD (eg, eosinophilic colitis). During 2011, 20 of the 60 patients who had maintained an IBD-indeterminate diagnosis were located and contacted, and detailed telephone interviews were conducted by the corresponding author. Two patients were reclassified as having CD (10%), one patient was reclassified as having eosinophilic colitis (5%), six patients remained with IBD-indeterminate (30%), and eleven patients (55%) reported a complete resolution of their symptoms. The follow-up period ranged from 10–18 years (mean 12.5 ± 3 years). Children who were reclassified as having CD were significantly younger than those who maintained an IBD-indeterminate diagnosis (6.4 ± 4 years versus11.2 ± 3 years, respectively, P = 0.05). CONCLUSION: Children with IBD-indeterminate remain classified as IBD-indeterminate, or were clinically reclassified as CD or non-IBD, or became asymptomatic as they transitioned into adulthood. The need for IBD-indeterminate classification is of importance, especially when deciding on management and treatment. Dove Medical Press 2013-07-23 /pmc/articles/PMC3726299/ /pubmed/23901288 http://dx.doi.org/10.2147/CEG.S44700 Text en © 2013 Malaty et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Malaty, Hoda M Mehta, Seema Abraham, Bincy Garnett, Elizabeth A Ferry, George D The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period |
title | The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period |
title_full | The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period |
title_fullStr | The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period |
title_full_unstemmed | The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period |
title_short | The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period |
title_sort | natural course of inflammatory bowel disease-indeterminate from childhood to adulthood: within a 25 year period |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726299/ https://www.ncbi.nlm.nih.gov/pubmed/23901288 http://dx.doi.org/10.2147/CEG.S44700 |
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