Ectopic Runx1 Expression Rescues Tal-1-Deficiency in the Generation of Primitive and Definitive Hematopoiesis

The transcription factors SCL/Tal-1 and AML1/Runx1 control the generation of pluripotent hematopoietic stem cells (pHSC) and, thereby, primitive and definitive hematopoiesis, during embryonic development of the mouse from mesoderm. Thus, Runx1-deficient mice generate primitive, but not definitive he...

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Detalles Bibliográficos
Autores principales: Tornack, Julia, Seiler, Katharina, Grützkau, Andreas, Grün, Joachim R., Onodera, Masafumi, Melchers, Fritz, Tsuneto, Motokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726448/
https://www.ncbi.nlm.nih.gov/pubmed/23922928
http://dx.doi.org/10.1371/journal.pone.0070116

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