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Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT

BACKGROUND: In-room cone-beam computerized tomography (CBCT) imaging is a promising method to reduce setup errors, especially in organs such as the bladder that often have large intrafractional variations due to organ movement. CBCT image quality is limited by low contrast and imaging artifacts, but...

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Autores principales: Nishioka, Kentaro, Shimizu, Shinichi, Kinoshita, Rumiko, Inoue, Tetsuya, Onodera, Shunsuke, Yasuda, Koichi, Harada, Keiichi, Nishikawa, Yukiko, Onimaru, Rikiya, Shirato, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726473/
https://www.ncbi.nlm.nih.gov/pubmed/23879876
http://dx.doi.org/10.1186/1748-717X-8-185
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author Nishioka, Kentaro
Shimizu, Shinichi
Kinoshita, Rumiko
Inoue, Tetsuya
Onodera, Shunsuke
Yasuda, Koichi
Harada, Keiichi
Nishikawa, Yukiko
Onimaru, Rikiya
Shirato, Hiroki
author_facet Nishioka, Kentaro
Shimizu, Shinichi
Kinoshita, Rumiko
Inoue, Tetsuya
Onodera, Shunsuke
Yasuda, Koichi
Harada, Keiichi
Nishikawa, Yukiko
Onimaru, Rikiya
Shirato, Hiroki
author_sort Nishioka, Kentaro
collection PubMed
description BACKGROUND: In-room cone-beam computerized tomography (CBCT) imaging is a promising method to reduce setup errors, especially in organs such as the bladder that often have large intrafractional variations due to organ movement. CBCT image quality is limited by low contrast and imaging artifacts, but few data have been reported about inter-observer variability of bladder boundary delineation on CBCT. The aim of this work was to analyze and evaluate the inter-observer contouring uncertainties of bladder boundary delineation on CBCT images in a prospective fashion. METHODS: Five radiation oncologists contoured 10 bladders using the CBCT datasets of consecutive 10 patients (including 4 females) who were irradiated to the pelvic region. Prostates were also contoured in male patients. Patients who had had prostatectomy were excluded. The coefficient of variation (COV), conformity index (CI(gen)), and coordinates of center-of-mass (COM) of the bladder and prostate were calculated for each patient. RESULTS: The mean COV for the bladder and prostate was 0.08 and 0.20, respectively. The mean CI(gen) of the bladder and prostate was 0.81 and 0.66, respectively. The root mean square (RMS) of the inter-observer standard deviation (σ) of the COM displacement in the left-right (LR) and anterior-posterior (AP) direction was 0.79, 0.87 and 0.54 for the bladder and 0.63, 0.99 and 1.72 for the prostate. Regarding the mean COV and CI(gen) for the bladder, the differences between males and females were not significant. CONCLUSIONS: Inter-observer variability for bladder delineation on CBCT images was substantially small regardless of gender. We believe that our results support the applicability of CBCT in adaptive radiotherapy for bladder cancer.
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spelling pubmed-37264732013-07-31 Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT Nishioka, Kentaro Shimizu, Shinichi Kinoshita, Rumiko Inoue, Tetsuya Onodera, Shunsuke Yasuda, Koichi Harada, Keiichi Nishikawa, Yukiko Onimaru, Rikiya Shirato, Hiroki Radiat Oncol Research BACKGROUND: In-room cone-beam computerized tomography (CBCT) imaging is a promising method to reduce setup errors, especially in organs such as the bladder that often have large intrafractional variations due to organ movement. CBCT image quality is limited by low contrast and imaging artifacts, but few data have been reported about inter-observer variability of bladder boundary delineation on CBCT. The aim of this work was to analyze and evaluate the inter-observer contouring uncertainties of bladder boundary delineation on CBCT images in a prospective fashion. METHODS: Five radiation oncologists contoured 10 bladders using the CBCT datasets of consecutive 10 patients (including 4 females) who were irradiated to the pelvic region. Prostates were also contoured in male patients. Patients who had had prostatectomy were excluded. The coefficient of variation (COV), conformity index (CI(gen)), and coordinates of center-of-mass (COM) of the bladder and prostate were calculated for each patient. RESULTS: The mean COV for the bladder and prostate was 0.08 and 0.20, respectively. The mean CI(gen) of the bladder and prostate was 0.81 and 0.66, respectively. The root mean square (RMS) of the inter-observer standard deviation (σ) of the COM displacement in the left-right (LR) and anterior-posterior (AP) direction was 0.79, 0.87 and 0.54 for the bladder and 0.63, 0.99 and 1.72 for the prostate. Regarding the mean COV and CI(gen) for the bladder, the differences between males and females were not significant. CONCLUSIONS: Inter-observer variability for bladder delineation on CBCT images was substantially small regardless of gender. We believe that our results support the applicability of CBCT in adaptive radiotherapy for bladder cancer. BioMed Central 2013-07-23 /pmc/articles/PMC3726473/ /pubmed/23879876 http://dx.doi.org/10.1186/1748-717X-8-185 Text en Copyright © 2013 Nishioka et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Nishioka, Kentaro
Shimizu, Shinichi
Kinoshita, Rumiko
Inoue, Tetsuya
Onodera, Shunsuke
Yasuda, Koichi
Harada, Keiichi
Nishikawa, Yukiko
Onimaru, Rikiya
Shirato, Hiroki
Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT
title Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT
title_full Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT
title_fullStr Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT
title_full_unstemmed Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT
title_short Evaluation of inter-observer variability of bladder boundary delineation on cone-beam CT
title_sort evaluation of inter-observer variability of bladder boundary delineation on cone-beam ct
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726473/
https://www.ncbi.nlm.nih.gov/pubmed/23879876
http://dx.doi.org/10.1186/1748-717X-8-185
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