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Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling
ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in var...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726583/ https://www.ncbi.nlm.nih.gov/pubmed/23458732 http://dx.doi.org/10.1016/j.mam.2013.02.002 |
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author | Karlberg, Tobias Langelier, Marie-France Pascal, John M. Schüler, Herwig |
author_facet | Karlberg, Tobias Langelier, Marie-France Pascal, John M. Schüler, Herwig |
author_sort | Karlberg, Tobias |
collection | PubMed |
description | ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation. |
format | Online Article Text |
id | pubmed-3726583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37265832014-12-01 Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling Karlberg, Tobias Langelier, Marie-France Pascal, John M. Schüler, Herwig Mol Aspects Med Article ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation. Elsevier Ltd. 2013-12 2013-02-28 /pmc/articles/PMC3726583/ /pubmed/23458732 http://dx.doi.org/10.1016/j.mam.2013.02.002 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Karlberg, Tobias Langelier, Marie-France Pascal, John M. Schüler, Herwig Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling |
title | Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling |
title_full | Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling |
title_fullStr | Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling |
title_full_unstemmed | Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling |
title_short | Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling |
title_sort | structural biology of the writers, readers, and erasers in mono- and poly(adp-ribose) mediated signaling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726583/ https://www.ncbi.nlm.nih.gov/pubmed/23458732 http://dx.doi.org/10.1016/j.mam.2013.02.002 |
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