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Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine

Ischemia reperfusion injury (IRI) in organ transplantation remains a serious and unsolved problem. Organs that undergo significant damage during IRI, function less well immediately after reperfusion and tend to have more problems at later times when rejection can occur. Biliverdin has emerged as an...

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Autores principales: Andria, Barbara, Bracco, Adele, Attanasio, Chiara, Castaldo, Sigismondo, Cerrito, Maria Grazia, Cozzolino, Santolo, Di Napoli, Daniele, Giovannoni, Roberto, Mancini, Antonio, Musumeci, Antonino, Mezza, Ernesto, Nasti, Mario, Scuderi, Vincenzo, Staibano, Stefania, Lavitrano, Marialuisa, Otterbein, Leo E., Calise, Fulvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726748/
https://www.ncbi.nlm.nih.gov/pubmed/23922878
http://dx.doi.org/10.1371/journal.pone.0069972
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author Andria, Barbara
Bracco, Adele
Attanasio, Chiara
Castaldo, Sigismondo
Cerrito, Maria Grazia
Cozzolino, Santolo
Di Napoli, Daniele
Giovannoni, Roberto
Mancini, Antonio
Musumeci, Antonino
Mezza, Ernesto
Nasti, Mario
Scuderi, Vincenzo
Staibano, Stefania
Lavitrano, Marialuisa
Otterbein, Leo E.
Calise, Fulvio
author_facet Andria, Barbara
Bracco, Adele
Attanasio, Chiara
Castaldo, Sigismondo
Cerrito, Maria Grazia
Cozzolino, Santolo
Di Napoli, Daniele
Giovannoni, Roberto
Mancini, Antonio
Musumeci, Antonino
Mezza, Ernesto
Nasti, Mario
Scuderi, Vincenzo
Staibano, Stefania
Lavitrano, Marialuisa
Otterbein, Leo E.
Calise, Fulvio
author_sort Andria, Barbara
collection PubMed
description Ischemia reperfusion injury (IRI) in organ transplantation remains a serious and unsolved problem. Organs that undergo significant damage during IRI, function less well immediately after reperfusion and tend to have more problems at later times when rejection can occur. Biliverdin has emerged as an agent that potently suppress IRI in rodent models. Since the use of biliverdin is being developed as a potential therapeutic modality for humans, we tested the efficacy for its effects on IRI of the liver in swine, an accepted and relevant pre-clinical animal model. Administration of biliverdin resulted in rapid appearance of bilirubin in the serum and significantly suppressed IRI-induced liver dysfunction as measured by multiple parameters including urea and ammonia clearance, neutrophil infiltration and tissue histopathology including hepatocyte cell death. Taken together, our findings, in a large animal model, provide strong support for the continued evaluation of biliverdin as a potential therapeutic in the clinical setting of transplantation of the liver and perhaps other organs.
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spelling pubmed-37267482013-08-06 Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine Andria, Barbara Bracco, Adele Attanasio, Chiara Castaldo, Sigismondo Cerrito, Maria Grazia Cozzolino, Santolo Di Napoli, Daniele Giovannoni, Roberto Mancini, Antonio Musumeci, Antonino Mezza, Ernesto Nasti, Mario Scuderi, Vincenzo Staibano, Stefania Lavitrano, Marialuisa Otterbein, Leo E. Calise, Fulvio PLoS One Research Article Ischemia reperfusion injury (IRI) in organ transplantation remains a serious and unsolved problem. Organs that undergo significant damage during IRI, function less well immediately after reperfusion and tend to have more problems at later times when rejection can occur. Biliverdin has emerged as an agent that potently suppress IRI in rodent models. Since the use of biliverdin is being developed as a potential therapeutic modality for humans, we tested the efficacy for its effects on IRI of the liver in swine, an accepted and relevant pre-clinical animal model. Administration of biliverdin resulted in rapid appearance of bilirubin in the serum and significantly suppressed IRI-induced liver dysfunction as measured by multiple parameters including urea and ammonia clearance, neutrophil infiltration and tissue histopathology including hepatocyte cell death. Taken together, our findings, in a large animal model, provide strong support for the continued evaluation of biliverdin as a potential therapeutic in the clinical setting of transplantation of the liver and perhaps other organs. Public Library of Science 2013-07-29 /pmc/articles/PMC3726748/ /pubmed/23922878 http://dx.doi.org/10.1371/journal.pone.0069972 Text en © 2013 Andria et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Andria, Barbara
Bracco, Adele
Attanasio, Chiara
Castaldo, Sigismondo
Cerrito, Maria Grazia
Cozzolino, Santolo
Di Napoli, Daniele
Giovannoni, Roberto
Mancini, Antonio
Musumeci, Antonino
Mezza, Ernesto
Nasti, Mario
Scuderi, Vincenzo
Staibano, Stefania
Lavitrano, Marialuisa
Otterbein, Leo E.
Calise, Fulvio
Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine
title Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine
title_full Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine
title_fullStr Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine
title_full_unstemmed Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine
title_short Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine
title_sort biliverdin protects against liver ischemia reperfusion injury in swine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726748/
https://www.ncbi.nlm.nih.gov/pubmed/23922878
http://dx.doi.org/10.1371/journal.pone.0069972
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