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Synthesis and Biological Activity of N-Sulfonyltripeptides with C-Terminal Arginine as Potential Serine Proteases Inhibitors

Tripeptides of the general X-SO(2)-d-Ser-AA-Arg-CO-Y formula, where X = α-tolyl, p-tolyl, 2,4,6-triisopropylphenyl; AA = alanine, glycine, norvaline and Y = OH, NH-(CH(2))(5)NH(2) were obtained and tested for their effect on the amidolytic activities of urokinase, thrombin, trypsin, plasmin, t-PA an...

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Detalles Bibliográficos
Autores principales: Markowska, Agnieszka, Bruzgo, Magdalena, Gorodkiewicz, Ewa, Surażyński, Arkadiusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726930/
https://www.ncbi.nlm.nih.gov/pubmed/23926446
http://dx.doi.org/10.1007/s10989-012-9338-4