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Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior

Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence sug...

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Autores principales: Barson, Jessica R., Morganstern, Irene, Leibowitz, Sarah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727095/
https://www.ncbi.nlm.nih.gov/pubmed/23935621
http://dx.doi.org/10.1155/2013/983964
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author Barson, Jessica R.
Morganstern, Irene
Leibowitz, Sarah F.
author_facet Barson, Jessica R.
Morganstern, Irene
Leibowitz, Sarah F.
author_sort Barson, Jessica R.
collection PubMed
description Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food.
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spelling pubmed-37270952013-08-09 Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior Barson, Jessica R. Morganstern, Irene Leibowitz, Sarah F. Int J Endocrinol Review Article Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food. Hindawi Publishing Corporation 2013 2013-07-11 /pmc/articles/PMC3727095/ /pubmed/23935621 http://dx.doi.org/10.1155/2013/983964 Text en Copyright © 2013 Jessica R. Barson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Barson, Jessica R.
Morganstern, Irene
Leibowitz, Sarah F.
Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
title Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
title_full Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
title_fullStr Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
title_full_unstemmed Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
title_short Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior
title_sort complementary roles of orexin and melanin-concentrating hormone in feeding behavior
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727095/
https://www.ncbi.nlm.nih.gov/pubmed/23935621
http://dx.doi.org/10.1155/2013/983964
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