Cargando…

Ocotillol Enhanced the Antitumor Activity of Doxorubicin via p53-Dependent Apoptosis

The use of doxorubicin (Dox) was severely constrained by dose-dependent side effects, which might be attenuated by combining a “sensitizer” to decrease its cumulative dosage. In this study, it was investigated whether ocotillol could enhance the antiproliferation activity of Dox. MTT assays and xeno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hongbo, Yu, Pengfei, Bai, Jing, Zhang, Jianqiao, Kong, Liang, Zhang, Fangxi, Du, Guangying, Pei, Shiqian, Zhang, Lixia, Jiang, Yongtao, Tian, Jingwei, Fu, Fenghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727205/ https://www.ncbi.nlm.nih.gov/pubmed/23956772 http://dx.doi.org/10.1155/2013/468537

Ejemplares similares

Preparation, Pharmacokinetics, Biodistribution, Antitumor Efficacy and Safety of Lx2-32c-Containing Liposome
por: Wang, Hongbo, et al.
Publicado: (2014)

The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo
por: Wang, Hongbo, et al.
Publicado: (2014)

Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
por: Liu, Juan, et al.
Publicado: (2017)

Recent Advances in the Semisynthesis, Modifications and Biological Activities of Ocotillol-Type Triterpenoids
por: Cao, Yucheng, et al.
Publicado: (2020)

Design, Synthesis and Antibacterial Evaluation of 3-Substituted Ocotillol-Type Derivatives
por: Wang, Kai-Yi, et al.
Publicado: (2018)

Synthesis and Anti-Hepatocarcinoma Effect of Amino Acid Derivatives of Pyxinol and Ocotillol
por: Zhang, Ying, et al.
Publicado: (2021)

Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics
por: Wang, Cuizhu, et al.
Publicado: (2020)

Synthesis and Antibacterial Evaluation of Novel 3-Substituted Ocotillol-Type Derivatives as Leads
por: Bi, Yi, et al.
Publicado: (2017)

Design, Synthesis, and Antibacterial Evaluation of Novel Ocotillol Derivatives and Their Synergistic Effects with Conventional Antibiotics
por: Zhang, Doudou, et al.
Publicado: (2021)

Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents
por: Zhang, Yun-Kai, et al.
Publicado: (2015)

Comparative genomics reveals the diversification of triterpenoid biosynthesis and origin of ocotillol-type triterpenes in Panax
por: Yang, Zijiang, et al.
Publicado: (2023)

Protection of Pyruvate against Glutamate Excitotoxicity Is Mediated by Regulating DAPK1 Protein Complex
por: Tian, Jingwei, et al.
Publicado: (2014)

PCC0208018 exerts antitumor effects by activating effector T cells
por: Ge, Minmin, et al.
Publicado: (2019)

Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers
por: Zhang, Guang-Hui, et al.
Publicado: (2015)

Stereoselective Property of 20(S)-Protopanaxadiol Ocotillol Type Epimers Affects Its Absorption and Also the Inhibition of P-Glycoprotein
por: Wang, Wenyan, et al.
Publicado: (2014)

Quercetin Potentiates Doxorubicin Mediated Antitumor Effects against Liver Cancer through p53/Bcl-xl
por: Wang, Guanyu, et al.
Publicado: (2012)

Chidamide Combined With Doxorubicin Induced p53-Driven Cell Cycle Arrest and Cell Apoptosis Reverse Multidrug Resistance of Breast Cancer
por: Cao, Lixia, et al.
Publicado: (2021)

NSK-01105, a Novel Sorafenib Derivative, Inhibits Human Prostate Tumor Growth via Suppression of VEGFR2/EGFR-Mediated Angiogenesis
por: Yu, Pengfei, et al.
Publicado: (2014)

Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model
por: Meng, Xiangjing, et al.
Publicado: (2017)

Antidepressant-like activity of adhyperforin, a novel constituent of Hypericum perforatum L.
por: Tian, Jingwei, et al.
Publicado: (2014)

LPM3770277, a Potent Novel CDK4/6 Degrader, Exerts Antitumor Effect Against Triple-Negative Breast Cancer
por: Qiu, Jiahao, et al.
Publicado: (2022)

Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo
por: Wang, Hongbo, et al.
Publicado: (2012)

Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes
por: Li, Kai, et al.
Publicado: (2017)

PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice
por: Hu, Zhengping, et al.
Publicado: (2020)

Lenvatinib Promotes the Antitumor Effect of Doxorubicin in Anaplastic Thyroid Cancer
por: Su, Xi, et al.
Publicado: (2020)

Silencing NOB1 enhances doxorubicin antitumor activity of the papillary thyroid carcinoma in vitro and in vivo
por: Liu, Jia, et al.
Publicado: (2022)

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo
por: Lv, Guangyao, et al.
Publicado: (2017)

A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin
por: Tang, H-J, et al.
Publicado: (2004)

Doxorubicin-loaded dual-functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo
por: Tian, Guixiang, et al.
Publicado: (2019)

Antidepressant-like Effects of LPM580153, A Novel Potent Triple Reuptake Inhibitor
por: Zhang, Fangxi, et al.
Publicado: (2016)

Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity
por: Wang, Jiye, et al.
Publicado: (2017)

Cationic Polymethacrylate-Modified Liposomes Significantly Enhanced Doxorubicin Delivery and Antitumor Activity
por: Wang, Wenxi, et al.
Publicado: (2017)

Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity
por: Zhang, Xin, et al.
Publicado: (2019)

miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity
por: Pan, Jian-An, et al.
Publicado: (2019)

Comparison study of different indoleamine-2,3 dioxygenase inhibitors from the perspective of pharmacodynamic effects
por: Jiang, Xue, et al.
Publicado: (2020)

tRNA Binding to Antitumor Drug Doxorubicin and Its Analogue
por: Agudelo, Daniel, et al.
Publicado: (2013)

Membrane Transport and Antitumor Activity of Pirarubicin, and Comparison with Those of Doxorubicin
por: Sugiyama, Tomomi, et al.
Publicado: (1999)

Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells
por: Kazantseva, Liliya, et al.
Publicado: (2021)

In Vivo Antitumoral Effects of Linseed Oil and Its Combination With Doxorubicin
por: Shadyro, Oleg, et al.
Publicado: (2022)

Design, synthesis, and bioactivity evaluation of antitumor sorafenib analogues
por: Zhou, Shiyang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9q5njtop17kkodniiknsn3hu2r