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Experimental evolution of protein–protein interaction networks

The modern synthesis of evolutionary theory and genetics has enabled us to discover underlying molecular mechanisms of organismal evolution. We know that in order to maximize an organism's fitness in a particular environment, individual interactions among components of protein and nucleic acid...

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Detalles Bibliográficos
Autores principales: Kaçar, Betül, Gaucher, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727214/
https://www.ncbi.nlm.nih.gov/pubmed/23849056
http://dx.doi.org/10.1042/BJ20130205
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author Kaçar, Betül
Gaucher, Eric A.
author_facet Kaçar, Betül
Gaucher, Eric A.
author_sort Kaçar, Betül
collection PubMed
description The modern synthesis of evolutionary theory and genetics has enabled us to discover underlying molecular mechanisms of organismal evolution. We know that in order to maximize an organism's fitness in a particular environment, individual interactions among components of protein and nucleic acid networks need to be optimized by natural selection, or sometimes through random processes, as the organism responds to changes and/or challenges in the environment. Despite the significant role of molecular networks in determining an organism's adaptation to its environment, we still do not know how such inter- and intra-molecular interactions within networks change over time and contribute to an organism's evolvability while maintaining overall network functions. One way to address this challenge is to identify connections between molecular networks and their host organisms, to manipulate these connections, and then attempt to understand how such perturbations influence molecular dynamics of the network and thus influence evolutionary paths and organismal fitness. In the present review, we discuss how integrating evolutionary history with experimental systems that combine tools drawn from molecular evolution, synthetic biology and biochemistry allow us to identify the underlying mechanisms of organismal evolution, particularly from the perspective of protein interaction networks.
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spelling pubmed-37272142013-08-06 Experimental evolution of protein–protein interaction networks Kaçar, Betül Gaucher, Eric A. Biochem J Review Article The modern synthesis of evolutionary theory and genetics has enabled us to discover underlying molecular mechanisms of organismal evolution. We know that in order to maximize an organism's fitness in a particular environment, individual interactions among components of protein and nucleic acid networks need to be optimized by natural selection, or sometimes through random processes, as the organism responds to changes and/or challenges in the environment. Despite the significant role of molecular networks in determining an organism's adaptation to its environment, we still do not know how such inter- and intra-molecular interactions within networks change over time and contribute to an organism's evolvability while maintaining overall network functions. One way to address this challenge is to identify connections between molecular networks and their host organisms, to manipulate these connections, and then attempt to understand how such perturbations influence molecular dynamics of the network and thus influence evolutionary paths and organismal fitness. In the present review, we discuss how integrating evolutionary history with experimental systems that combine tools drawn from molecular evolution, synthetic biology and biochemistry allow us to identify the underlying mechanisms of organismal evolution, particularly from the perspective of protein interaction networks. Portland Press Ltd. 2013-07-12 2013-08-01 /pmc/articles/PMC3727214/ /pubmed/23849056 http://dx.doi.org/10.1042/BJ20130205 Text en © 2013 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kaçar, Betül
Gaucher, Eric A.
Experimental evolution of protein–protein interaction networks
title Experimental evolution of protein–protein interaction networks
title_full Experimental evolution of protein–protein interaction networks
title_fullStr Experimental evolution of protein–protein interaction networks
title_full_unstemmed Experimental evolution of protein–protein interaction networks
title_short Experimental evolution of protein–protein interaction networks
title_sort experimental evolution of protein–protein interaction networks
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727214/
https://www.ncbi.nlm.nih.gov/pubmed/23849056
http://dx.doi.org/10.1042/BJ20130205
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