Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

The commonest pediatric brain tumors are low-grade gliomas (LGGs). We utilized whole genome sequencing to discover multiple novel genetic alterations involving BRAF, RAF1, FGFR1, MYB, MYBL1 and genes with histone-related functions, including H3F3A and ATRX, in 39 LGGs and low-grade glioneuronal tumo...

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Autores principales: Zhang, Jinghui, Wu, Gang, Miller, Claudia P., Tatevossian, Ruth G., Dalton, James D., Tang, Bo, Orisme, Wilda, Punchihewa, Chandanamali, Parker, Matthew, Qaddoumi, Ibrahim, Boop, Fredrick A., Lu, Charles, Kandoth, Cyriac, Ding, Li, Lee, Ryan, Huether, Robert, Chen, Xiang, Hedlund, Erin, Nagahawatte, Panduka, Rusch, Michael, Boggs, Kristy, Cheng, Jinjun, Becksfort, Jared, Ma, Jing, Song, Guangchun, Li, Yongjin, Wei, Lei, Wang, Jianmin, Shurtleff, Sheila, Easton, John, Zhao, David, Fulton, Robert S., Fulton, Lucinda L., Dooling, David J., Vadodaria, Bhavin, Mulder, Heather L., Tang, Chunlao, Ochoa, Kerri, Mullighan, Charles G., Gajjar, Amar, Kriwacki, Richard, Sheer, Denise, Gilbertson, Richard J., Mardis, Elaine R., Wilson, Richard K., Downing, James R., Baker, Suzanne J., Ellison, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727232/
https://www.ncbi.nlm.nih.gov/pubmed/23583981
http://dx.doi.org/10.1038/ng.2611

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