Diminished Functional Role and Altered Localization of Shp2 in Non-Small Cell Lung Cancer Cells With Egfr-Activating Mutations

Non-small cell lung cancer (NSCLC) cells harboring activating mutations of the epidermal growth factor receptor (EGFR) tend to display elevated activity of several survival signaling pathways. Surprisingly, these mutations also correlate with reduced phosphorylation of ERK and SHP2, a protein tyrosi...

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Detalles Bibliográficos
Autores principales: Furcht, Christopher M., Rojas, Andres Muñoz, Nihalani, Deepak, Lazzara, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727284/
https://www.ncbi.nlm.nih.gov/pubmed/22777356
http://dx.doi.org/10.1038/onc.2012.240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727284/
https://www.ncbi.nlm.nih.gov/pubmed/22777356
http://dx.doi.org/10.1038/onc.2012.240

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