USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1–TAB1 complex

Reversible ubiquitin modification of cell signaling molecules has emerged as a critical mechanism by which cells respond to extracellular stimuli. Although ubiquitination of TGF-β–activated kinase 1 (TAK1) is critical for NF-κB activation in T cells, the regulation of its deubiquitination is unclear...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xikui, Li, Hongxiu, Zhong, Bo, Blonska, Marzenna, Gorjestani, Sara, Yan, Ming, Tian, Qiang, Zhang, Dong-Er, Lin, Xin, Dong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727316/
https://www.ncbi.nlm.nih.gov/pubmed/23825189
http://dx.doi.org/10.1084/jem.20122327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727316/
https://www.ncbi.nlm.nih.gov/pubmed/23825189
http://dx.doi.org/10.1084/jem.20122327

Ejemplares similares