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The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

Interactions with cognate antigens recruit activated B cells into germinal centers where they undergo somatic hypermutation (SHM) in V(D)J exons for the generation of high-affinity antibodies. The contribution of IgH transcriptional enhancers in SHM is unclear. The E(μ) enhancer upstream of C(μ) has...

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Detalles Bibliográficos
Autores principales:	Rouaud, Pauline, Vincent-Fabert, Christelle, Saintamand, Alexis, Fiancette, Rémi, Marquet, Marie, Robert, Isabelle, Reina-San-Martin, Bernardo, Pinaud, Eric, Cogné, Michel, Denizot, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727322/ https://www.ncbi.nlm.nih.gov/pubmed/23825188 http://dx.doi.org/10.1084/jem.20130072

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