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Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
Sensitive and reliable behavioral outcome measures are essential to the evaluation of potential therapeutic treatments in preclinical trials for many neurodegenerative diseases. In Parkinson's disease, sensorimotor tests sensitive to varying degrees of nigrostriatal dysfunction are fundamental...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MyJove Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727502/ https://www.ncbi.nlm.nih.gov/pubmed/23851663 http://dx.doi.org/10.3791/50303 |
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author | Fleming, Sheila M. Ekhator, Osunde R. Ghisays, Valentins |
author_facet | Fleming, Sheila M. Ekhator, Osunde R. Ghisays, Valentins |
author_sort | Fleming, Sheila M. |
collection | PubMed |
description | Sensitive and reliable behavioral outcome measures are essential to the evaluation of potential therapeutic treatments in preclinical trials for many neurodegenerative diseases. In Parkinson's disease, sensorimotor tests sensitive to varying degrees of nigrostriatal dysfunction are fundamental for testing the efficacy of potential therapeutics. Reliable and quite elegant sensorimotor measures exist for rats, however many of these tests measure sensorimotor asymmetry within the rat and are not entirely suitable for the newer genetic mouse models of PD. We have put together a battery of sensorimotor tests inspired by the sensitive tests in rats and adapted for mice. The test battery highlighted in this study is chosen for a) its sensitivity in a wide variety of mouse models of PD, b) its ease in implementing into a study, and c) its low expense. These tests have proven useful in characterizing novel genetic mouse models of PD as well as in testing potential disease-modifying therapies. |
format | Online Article Text |
id | pubmed-3727502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MyJove Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37275022013-08-06 Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease Fleming, Sheila M. Ekhator, Osunde R. Ghisays, Valentins J Vis Exp Behavior Sensitive and reliable behavioral outcome measures are essential to the evaluation of potential therapeutic treatments in preclinical trials for many neurodegenerative diseases. In Parkinson's disease, sensorimotor tests sensitive to varying degrees of nigrostriatal dysfunction are fundamental for testing the efficacy of potential therapeutics. Reliable and quite elegant sensorimotor measures exist for rats, however many of these tests measure sensorimotor asymmetry within the rat and are not entirely suitable for the newer genetic mouse models of PD. We have put together a battery of sensorimotor tests inspired by the sensitive tests in rats and adapted for mice. The test battery highlighted in this study is chosen for a) its sensitivity in a wide variety of mouse models of PD, b) its ease in implementing into a study, and c) its low expense. These tests have proven useful in characterizing novel genetic mouse models of PD as well as in testing potential disease-modifying therapies. MyJove Corporation 2013-06-17 /pmc/articles/PMC3727502/ /pubmed/23851663 http://dx.doi.org/10.3791/50303 Text en Copyright © 2013, Journal of Visualized Experiments http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visithttp://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Behavior Fleming, Sheila M. Ekhator, Osunde R. Ghisays, Valentins Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease |
title | Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease |
title_full | Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease |
title_fullStr | Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease |
title_full_unstemmed | Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease |
title_short | Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease |
title_sort | assessment of sensorimotor function in mouse models of parkinson's disease |
topic | Behavior |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727502/ https://www.ncbi.nlm.nih.gov/pubmed/23851663 http://dx.doi.org/10.3791/50303 |
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