Shiga toxin–binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms

Shiga toxicosis is caused by retrograde trafficking of one of three types of Shiga toxin (STx), STx, STx1, or STx2. Trafficking depends on the toxin B subunits, which for STx and STx1 are identical and bind GPP130, a manganese (Mn)-sensitive intracellular trafficking receptor. Elevated Mn down-regul...

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Detalles Bibliográficos
Autores principales: Mukhopadhyay, Somshuvra, Redler, Brendan, Linstedt, Adam D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727924/
https://www.ncbi.nlm.nih.gov/pubmed/23761068
http://dx.doi.org/10.1091/mbc.E13-01-0057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727924/
https://www.ncbi.nlm.nih.gov/pubmed/23761068
http://dx.doi.org/10.1091/mbc.E13-01-0057

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