Improvement of Pharmacokinetics Behavior of Apocynin by Nitrone Derivatization: Comparative Pharmacokinetics of Nitrone-Apocynin and its Parent Apocynin in Rats

Apocynin, a potent inhibitor of NADPH-oxidase, was widely studied for activities in diseases such as inflammation-mediated disorders, asthma and cardiovascular diseases. In our recent study, a novel nitrone derivative of apocynin, AN-1, demonstrated potent inhibition to oxidative injury and to high...

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Detalles Bibliográficos
Autores principales: Wang, Kaiyu, Li, Linlin, Song, Yan, Ye, Xiaocui, Fu, Shaolian, Jiang, Jie, Li, Sha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728092/
https://www.ncbi.nlm.nih.gov/pubmed/23936162
http://dx.doi.org/10.1371/journal.pone.0070189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728092/
https://www.ncbi.nlm.nih.gov/pubmed/23936162
http://dx.doi.org/10.1371/journal.pone.0070189

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