Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene

We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and w...

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Detalles Bibliográficos
Autores principales: Bellesso, Marcelo, Santucci, Rodrigo, Dias, Daniela Ferreira, Centrone, Renato, Elias, Renata Campos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Hematologia e Hemoterapia 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728137/
https://www.ncbi.nlm.nih.gov/pubmed/23904814
http://dx.doi.org/10.5581/1516-8484.20130044
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author Bellesso, Marcelo
Santucci, Rodrigo
Dias, Daniela Ferreira
Centrone, Renato
Elias, Renata Campos
author_facet Bellesso, Marcelo
Santucci, Rodrigo
Dias, Daniela Ferreira
Centrone, Renato
Elias, Renata Campos
author_sort Bellesso, Marcelo
collection PubMed
description We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. Fifty-three days after the procedure, he died due to acute graft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations: myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid leukemia.
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spelling pubmed-37281372013-07-31 Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene Bellesso, Marcelo Santucci, Rodrigo Dias, Daniela Ferreira Centrone, Renato Elias, Renata Campos Rev Bras Hematol Hemoter Case Report We report here on a rare case of BCR-ABL1-negative atypical chronic myeloid leukemia with a t(9;22)(p24;q11.2)translocation and a BCR-JAK2 fusion gene, with resistance to the tyrosine kinase inhibitors imatinib and dasatinib.At two years of follow-up, the patient showed no hematologic response and was submitted to an allogeneic bonemarrow transplantation. Fifty-three days after the procedure, he died due to acute graft-versus-host disease. This BCR-JAK2 fusion gene has so far been found in only five patients in the whole world, with three clinical presentations: myeloproliferative neoplasm, acute lymphoblastic leukemia and acute myeloid leukemia. Associação Brasileira de Hematologia e Hemoterapia 2013 /pmc/articles/PMC3728137/ /pubmed/23904814 http://dx.doi.org/10.5581/1516-8484.20130044 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bellesso, Marcelo
Santucci, Rodrigo
Dias, Daniela Ferreira
Centrone, Renato
Elias, Renata Campos
Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene
title Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene
title_full Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene
title_fullStr Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene
title_full_unstemmed Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene
title_short Atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a BCR-JAK2 fusion gene
title_sort atypical chronic myeloid leukemia with t(9;22)(p24,11.2), a bcr-jak2 fusion gene
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728137/
https://www.ncbi.nlm.nih.gov/pubmed/23904814
http://dx.doi.org/10.5581/1516-8484.20130044
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