Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy

Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creati...

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Detalles Bibliográficos
Autores principales: Assadi, Mitra, Wang, Dah-Jyuu, Velazquez-Rodriquez, Yadira, Leone, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728201/
https://www.ncbi.nlm.nih.gov/pubmed/23926443
http://dx.doi.org/10.4137/JCNSD.S11861
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author Assadi, Mitra
Wang, Dah-Jyuu
Velazquez-Rodriquez, Yadira
Leone, Paola
author_facet Assadi, Mitra
Wang, Dah-Jyuu
Velazquez-Rodriquez, Yadira
Leone, Paola
author_sort Assadi, Mitra
collection PubMed
description Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creatine and lactate/creatine ratios as well as decreased N-acetyl aspartate/creatine ratios. We propose that elevation in myoinositol and lactate are caused by astrocytic gliosis and may be used as biomarkers for disease progression in MLD.
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spelling pubmed-37282012013-08-07 Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy Assadi, Mitra Wang, Dah-Jyuu Velazquez-Rodriquez, Yadira Leone, Paola J Cent Nerv Syst Dis Original Research Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creatine and lactate/creatine ratios as well as decreased N-acetyl aspartate/creatine ratios. We propose that elevation in myoinositol and lactate are caused by astrocytic gliosis and may be used as biomarkers for disease progression in MLD. Libertas Academica 2013-07-04 /pmc/articles/PMC3728201/ /pubmed/23926443 http://dx.doi.org/10.4137/JCNSD.S11861 Text en © 2013 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 license.
spellingShingle Original Research
Assadi, Mitra
Wang, Dah-Jyuu
Velazquez-Rodriquez, Yadira
Leone, Paola
Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy
title Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy
title_full Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy
title_fullStr Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy
title_full_unstemmed Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy
title_short Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy
title_sort multi-voxel 1h-mrs in metachromatic leukodystrophy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728201/
https://www.ncbi.nlm.nih.gov/pubmed/23926443
http://dx.doi.org/10.4137/JCNSD.S11861
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