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Mechanism of Protein Kinetic Stabilization by Engineered Disulfide Crosslinks

The impact of disulfide bonds on protein stability goes beyond simple equilibrium thermodynamics effects associated with the conformational entropy of the unfolded state. Indeed, disulfide crosslinks may play a role in the prevention of dysfunctional association and strongly affect the rates of irre...

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Detalles Bibliográficos
Autores principales:	Sanchez-Romero, Inmaculada, Ariza, Antonio, Wilson, Keith S., Skjøt, Michael, Vind, Jesper, De Maria, Leonardo, Skov, Lars K., Sanchez-Ruiz, Jose M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728334/ https://www.ncbi.nlm.nih.gov/pubmed/23936134 http://dx.doi.org/10.1371/journal.pone.0070013

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