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Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis
PURPOSE: Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis. METHODS: We examined 16 children attending the outpatient clinic at the CHA Bundang Medi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Pediatric Society
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728447/ https://www.ncbi.nlm.nih.gov/pubmed/23908668 http://dx.doi.org/10.3345/kjp.2013.56.7.286 |
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author | Baek, Ji Hyeon Seo, Hyun Kyong Jee, Hye Mi Shin, Youn Ho Han, Man Yong Oh, Eun Sang Lee, Hyun Ju Kim, Kyung Hyo |
author_facet | Baek, Ji Hyeon Seo, Hyun Kyong Jee, Hye Mi Shin, Youn Ho Han, Man Yong Oh, Eun Sang Lee, Hyun Ju Kim, Kyung Hyo |
author_sort | Baek, Ji Hyeon |
collection | PubMed |
description | PURPOSE: Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis. METHODS: We examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3.11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months or >3 times per year. The complete blood count with differential and total serum concentrations of Immunoglobulin (Ig) E, IgA, IgD, IgM, IgG, and IgG subclasses (IgG(1), IgG(2), IgG(3), and IgG(4)) of all children were measured. All subjects received 23-polysaccharide pneumococcal vaccination (PPV), and the levels of antibodies to 5 serologic types (4, 6B, 14, 18C, and 23F) of pneumococcal capsular polysaccharide antigens were measured before and after vaccination. Post-PPV antibody titers ≥0.35 µg/mL or with a ≥4-fold increase were considered as positive responses. RESULTS: The titers of IgG, IgA, IgD, and IgM were within normal range in all 16 children, whereas the total IgE concentration was higher than normal in 2 children. IgG(1) deficiency was observed in 1 patient and IgG(3) deficiency in 3. After PPV, 1 patient failed to respond to all 5 serologic types, 2 failed to respond to 4 serologic types, and 2 failed to respond to 3 serologic types. CONCLUSION: Clinicians should consider the evaluation of humoral immune functions in children with chronic or recurrent rhinosinusitis who do not respond to prolonged antibiotic treatment. |
format | Online Article Text |
id | pubmed-3728447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Pediatric Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-37284472013-08-01 Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis Baek, Ji Hyeon Seo, Hyun Kyong Jee, Hye Mi Shin, Youn Ho Han, Man Yong Oh, Eun Sang Lee, Hyun Ju Kim, Kyung Hyo Korean J Pediatr Original Article PURPOSE: Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis. METHODS: We examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3.11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months or >3 times per year. The complete blood count with differential and total serum concentrations of Immunoglobulin (Ig) E, IgA, IgD, IgM, IgG, and IgG subclasses (IgG(1), IgG(2), IgG(3), and IgG(4)) of all children were measured. All subjects received 23-polysaccharide pneumococcal vaccination (PPV), and the levels of antibodies to 5 serologic types (4, 6B, 14, 18C, and 23F) of pneumococcal capsular polysaccharide antigens were measured before and after vaccination. Post-PPV antibody titers ≥0.35 µg/mL or with a ≥4-fold increase were considered as positive responses. RESULTS: The titers of IgG, IgA, IgD, and IgM were within normal range in all 16 children, whereas the total IgE concentration was higher than normal in 2 children. IgG(1) deficiency was observed in 1 patient and IgG(3) deficiency in 3. After PPV, 1 patient failed to respond to all 5 serologic types, 2 failed to respond to 4 serologic types, and 2 failed to respond to 3 serologic types. CONCLUSION: Clinicians should consider the evaluation of humoral immune functions in children with chronic or recurrent rhinosinusitis who do not respond to prolonged antibiotic treatment. The Korean Pediatric Society 2013-07 2013-07-19 /pmc/articles/PMC3728447/ /pubmed/23908668 http://dx.doi.org/10.3345/kjp.2013.56.7.286 Text en Copyright © 2013 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Baek, Ji Hyeon Seo, Hyun Kyong Jee, Hye Mi Shin, Youn Ho Han, Man Yong Oh, Eun Sang Lee, Hyun Ju Kim, Kyung Hyo Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis |
title | Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis |
title_full | Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis |
title_fullStr | Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis |
title_full_unstemmed | Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis |
title_short | Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis |
title_sort | antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728447/ https://www.ncbi.nlm.nih.gov/pubmed/23908668 http://dx.doi.org/10.3345/kjp.2013.56.7.286 |
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