ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198

A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n = 27), covering the epidemic, only three showed distinct mutations in ramR resulting in...

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Autores principales: Baucheron, Sylvie, Le Hello, Simon, Doublet, Benoît, Giraud, Etienne, Weill, François-Xavier, Cloeckaert, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728480/
https://www.ncbi.nlm.nih.gov/pubmed/23914184
http://dx.doi.org/10.3389/fmicb.2013.00213
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author Baucheron, Sylvie
Le Hello, Simon
Doublet, Benoît
Giraud, Etienne
Weill, François-Xavier
Cloeckaert, Axel
author_facet Baucheron, Sylvie
Le Hello, Simon
Doublet, Benoît
Giraud, Etienne
Weill, François-Xavier
Cloeckaert, Axel
author_sort Baucheron, Sylvie
collection PubMed
description A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n = 27), covering the epidemic, only three showed distinct mutations in ramR resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxacin MIC. No mutations were detected in other regulatory regions of this efflux system. Ciprofloxacin resistance in serovar Kentucky ST198 is thus currently mainly due to multiple target gene mutations.
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spelling pubmed-37284802013-08-02 ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198 Baucheron, Sylvie Le Hello, Simon Doublet, Benoît Giraud, Etienne Weill, François-Xavier Cloeckaert, Axel Front Microbiol Microbiology A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n = 27), covering the epidemic, only three showed distinct mutations in ramR resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxacin MIC. No mutations were detected in other regulatory regions of this efflux system. Ciprofloxacin resistance in serovar Kentucky ST198 is thus currently mainly due to multiple target gene mutations. Frontiers Media S.A. 2013-07-31 /pmc/articles/PMC3728480/ /pubmed/23914184 http://dx.doi.org/10.3389/fmicb.2013.00213 Text en Copyright © 2013 Baucheron, Le Hello, Doublet, Giraud, Weill and Cloeckaert. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Baucheron, Sylvie
Le Hello, Simon
Doublet, Benoît
Giraud, Etienne
Weill, François-Xavier
Cloeckaert, Axel
ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198
title ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198
title_full ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198
title_fullStr ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198
title_full_unstemmed ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198
title_short ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198
title_sort ramr mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant salmonella enterica serovar kentucky st198
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728480/
https://www.ncbi.nlm.nih.gov/pubmed/23914184
http://dx.doi.org/10.3389/fmicb.2013.00213
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