Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases

T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential rol...

Descripción completa

Detalles Bibliográficos
Autores principales: Qu, Ning, Xu, Mingli, Mizoguchi, Izuru, Furusawa, Jun-ichi, Kaneko, Kotaro, Watanabe, Kazunori, Mizuguchi, Junichiro, Itoh, Masahiro, Kawakami, Yutaka, Yoshimoto, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728507/
https://www.ncbi.nlm.nih.gov/pubmed/23956763
http://dx.doi.org/10.1155/2013/968549
_version_ 1782278871838621696
author Qu, Ning
Xu, Mingli
Mizoguchi, Izuru
Furusawa, Jun-ichi
Kaneko, Kotaro
Watanabe, Kazunori
Mizuguchi, Junichiro
Itoh, Masahiro
Kawakami, Yutaka
Yoshimoto, Takayuki
author_facet Qu, Ning
Xu, Mingli
Mizoguchi, Izuru
Furusawa, Jun-ichi
Kaneko, Kotaro
Watanabe, Kazunori
Mizuguchi, Junichiro
Itoh, Masahiro
Kawakami, Yutaka
Yoshimoto, Takayuki
author_sort Qu, Ning
collection PubMed
description T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.
format Online
Article
Text
id pubmed-3728507
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37285072013-08-16 Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases Qu, Ning Xu, Mingli Mizoguchi, Izuru Furusawa, Jun-ichi Kaneko, Kotaro Watanabe, Kazunori Mizuguchi, Junichiro Itoh, Masahiro Kawakami, Yutaka Yoshimoto, Takayuki Clin Dev Immunol Review Article T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases. Hindawi Publishing Corporation 2013 2013-07-14 /pmc/articles/PMC3728507/ /pubmed/23956763 http://dx.doi.org/10.1155/2013/968549 Text en Copyright © 2013 Ning Qu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Qu, Ning
Xu, Mingli
Mizoguchi, Izuru
Furusawa, Jun-ichi
Kaneko, Kotaro
Watanabe, Kazunori
Mizuguchi, Junichiro
Itoh, Masahiro
Kawakami, Yutaka
Yoshimoto, Takayuki
Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
title Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
title_full Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
title_fullStr Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
title_full_unstemmed Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
title_short Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
title_sort pivotal roles of t-helper 17-related cytokines, il-17, il-22, and il-23, in inflammatory diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728507/
https://www.ncbi.nlm.nih.gov/pubmed/23956763
http://dx.doi.org/10.1155/2013/968549
work_keys_str_mv AT quning pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT xumingli pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT mizoguchiizuru pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT furusawajunichi pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT kanekokotaro pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT watanabekazunori pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT mizuguchijunichiro pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT itohmasahiro pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT kawakamiyutaka pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases
AT yoshimototakayuki pivotalrolesofthelper17relatedcytokinesil17il22andil23ininflammatorydiseases

Ejemplares similares