Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript

Chronic myeloid leukemia (CML) with the rare fusion gene e19a2, encoding a p230 protein, has been described in patients with typical or rather aggressive clinical course. Although tyrosine kinase inhibitors (TKIs) induce a substantial cytogenetic and molecular response in all phases of CML, a minori...

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Autores principales: Greco, Marianna, Caocci, Giovanni, La Nasa, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728508/
https://www.ncbi.nlm.nih.gov/pubmed/23956893
http://dx.doi.org/10.1155/2013/871476
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author Greco, Marianna
Caocci, Giovanni
La Nasa, Giorgio
author_facet Greco, Marianna
Caocci, Giovanni
La Nasa, Giorgio
author_sort Greco, Marianna
collection PubMed
description Chronic myeloid leukemia (CML) with the rare fusion gene e19a2, encoding a p230 protein, has been described in patients with typical or rather aggressive clinical course. Although tyrosine kinase inhibitors (TKIs) induce a substantial cytogenetic and molecular response in all phases of CML, a minority of p230 positive patients have been treated with TKIs. We report two cases of CML patients carrying the p230 transcript, who achieved fast and deep complete molecular response (CMR) after frontline treatment with nilotinib. Our results suggest the use of nilotinib as frontline agent for the treatment of this CML variant.
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spelling pubmed-37285082013-08-16 Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript Greco, Marianna Caocci, Giovanni La Nasa, Giorgio Case Rep Hematol Case Report Chronic myeloid leukemia (CML) with the rare fusion gene e19a2, encoding a p230 protein, has been described in patients with typical or rather aggressive clinical course. Although tyrosine kinase inhibitors (TKIs) induce a substantial cytogenetic and molecular response in all phases of CML, a minority of p230 positive patients have been treated with TKIs. We report two cases of CML patients carrying the p230 transcript, who achieved fast and deep complete molecular response (CMR) after frontline treatment with nilotinib. Our results suggest the use of nilotinib as frontline agent for the treatment of this CML variant. Hindawi Publishing Corporation 2013 2013-07-11 /pmc/articles/PMC3728508/ /pubmed/23956893 http://dx.doi.org/10.1155/2013/871476 Text en Copyright © 2013 Marianna Greco et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Greco, Marianna
Caocci, Giovanni
La Nasa, Giorgio
Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript
title Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript
title_full Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript
title_fullStr Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript
title_full_unstemmed Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript
title_short Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript
title_sort early complete molecular response to first-line nilotinib in two patients with chronic myeloid leukemia carrying the p230 transcript
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728508/
https://www.ncbi.nlm.nih.gov/pubmed/23956893
http://dx.doi.org/10.1155/2013/871476
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AT caoccigiovanni earlycompletemolecularresponsetofirstlinenilotinibintwopatientswithchronicmyeloidleukemiacarryingthep230transcript
AT lanasagiorgio earlycompletemolecularresponsetofirstlinenilotinibintwopatientswithchronicmyeloidleukemiacarryingthep230transcript

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