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Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells

Eukaryotic cells contain dynamic mitochondrial filaments: they fuse and divide. Here we summarize data on the protein machinery driving mitochondrial dynamics in yeast and also discuss the factors that affect the fusion-fission balance. Fission is a general stress response of cells, and in the case...

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Autores principales: Knorre, Dmitry A., Popadin, Konstantin Y., Sokolov, Svyatoslav S., Severin, Fedor F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728513/
https://www.ncbi.nlm.nih.gov/pubmed/23956814
http://dx.doi.org/10.1155/2013/139491
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author Knorre, Dmitry A.
Popadin, Konstantin Y.
Sokolov, Svyatoslav S.
Severin, Fedor F.
author_facet Knorre, Dmitry A.
Popadin, Konstantin Y.
Sokolov, Svyatoslav S.
Severin, Fedor F.
author_sort Knorre, Dmitry A.
collection PubMed
description Eukaryotic cells contain dynamic mitochondrial filaments: they fuse and divide. Here we summarize data on the protein machinery driving mitochondrial dynamics in yeast and also discuss the factors that affect the fusion-fission balance. Fission is a general stress response of cells, and in the case of yeast this response appears to be prosurvival. At the same time, even under normal conditions yeast mitochondria undergo continuous cycles of fusion and fission. This seems to be a futile cycle and also expensive from the energy point of view. Why does it exist? Benefits might be the same as in the case of sexual reproduction. Indeed, mixing and separating of mitochondrial content allows mitochondrial DNA to segregate and recombine randomly, leading to high variation in the numbers of mutations per individual mitochondrion. This opens a possibility for effective purifying selection-elimination of mitochondria highly contaminated by deleterious mutations. The beneficial action presumes a mechanism for removal of defective mitochondria. We argue that selective mitochondrial autophagy or asymmetrical distribution of mitochondria during cell division could be at the core of such mechanism.
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spelling pubmed-37285132013-08-16 Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells Knorre, Dmitry A. Popadin, Konstantin Y. Sokolov, Svyatoslav S. Severin, Fedor F. Oxid Med Cell Longev Review Article Eukaryotic cells contain dynamic mitochondrial filaments: they fuse and divide. Here we summarize data on the protein machinery driving mitochondrial dynamics in yeast and also discuss the factors that affect the fusion-fission balance. Fission is a general stress response of cells, and in the case of yeast this response appears to be prosurvival. At the same time, even under normal conditions yeast mitochondria undergo continuous cycles of fusion and fission. This seems to be a futile cycle and also expensive from the energy point of view. Why does it exist? Benefits might be the same as in the case of sexual reproduction. Indeed, mixing and separating of mitochondrial content allows mitochondrial DNA to segregate and recombine randomly, leading to high variation in the numbers of mutations per individual mitochondrion. This opens a possibility for effective purifying selection-elimination of mitochondria highly contaminated by deleterious mutations. The beneficial action presumes a mechanism for removal of defective mitochondria. We argue that selective mitochondrial autophagy or asymmetrical distribution of mitochondria during cell division could be at the core of such mechanism. Hindawi Publishing Corporation 2013 2013-07-14 /pmc/articles/PMC3728513/ /pubmed/23956814 http://dx.doi.org/10.1155/2013/139491 Text en Copyright © 2013 Dmitry A. Knorre et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Knorre, Dmitry A.
Popadin, Konstantin Y.
Sokolov, Svyatoslav S.
Severin, Fedor F.
Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells
title Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells
title_full Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells
title_fullStr Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells
title_full_unstemmed Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells
title_short Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells
title_sort roles of mitochondrial dynamics under stressful and normal conditions in yeast cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728513/
https://www.ncbi.nlm.nih.gov/pubmed/23956814
http://dx.doi.org/10.1155/2013/139491
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