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How to switch a master switch

The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.

Detalles Bibliográficos
Autores principales: Hein, Christopher, Wittinghofer, Alfred, Dötsch, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728619/
https://www.ncbi.nlm.nih.gov/pubmed/23908771
http://dx.doi.org/10.7554/eLife.01159
Descripción
Sumario:The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.