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White Matter Integrity Pre- and Post Marijuana and Alcohol Initiation in Adolescence

Characterizing the effects of alcohol and marijuana use on adolescent brain development is important for understanding potential alterations in neurodevelopment. Several cross sectional studies have identified group differences in white matter integrity after initiation of heavy alcohol and marijuan...

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Autores principales: Jacobus, Joanna, Squeglia, Lindsay M., Infante, M. Alejandra, Bava, Sunita, Tapert, Susan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728679/
https://www.ncbi.nlm.nih.gov/pubmed/23914300
http://dx.doi.org/10.3390/brainsci3010396
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author Jacobus, Joanna
Squeglia, Lindsay M.
Infante, M. Alejandra
Bava, Sunita
Tapert, Susan F.
author_facet Jacobus, Joanna
Squeglia, Lindsay M.
Infante, M. Alejandra
Bava, Sunita
Tapert, Susan F.
author_sort Jacobus, Joanna
collection PubMed
description Characterizing the effects of alcohol and marijuana use on adolescent brain development is important for understanding potential alterations in neurodevelopment. Several cross sectional studies have identified group differences in white matter integrity after initiation of heavy alcohol and marijuana use, however none have explored white matter trajectories in adolescents pre- and post initiation of use, particularly for marijuana users. This study followed 16 adolescents with minimal alcohol and marijuana use at ages 16–18 over three years. At follow-up, teens were 19–22 years old; half of the participants initiated heavy alcohol use and half initiated heavy alcohol and marijuana use. Repeated-measures ANOVA revealed 20 clusters in association and projection fibers tracts (p < 0.01) in which a group by time interaction was found. Most consistently, white matter integrity (i.e., fractional anisotropy) decreased for those who initiated both heavy alcohol and marijuana use over the follow-up interval. No effect of time or change in white matter integrity was seen for those who initiated alcohol use only in the majority of clusters. In most regions, at the baseline time point, teens who would later initiate both alcohol and marijuana use demonstrated white matter integrity greater than or equal to teens that initiated alcohol use only. Findings suggest poorer tissue integrity associated with combined initiation of heavy alcohol and marijuana use in late adolescence. While pre-existing differences may also be related to likelihood of substance use, the present data suggest an effect on tissue integrity for these teens transitioning to combined alcohol and marijuana use in later adolescence.
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spelling pubmed-37286792013-07-31 White Matter Integrity Pre- and Post Marijuana and Alcohol Initiation in Adolescence Jacobus, Joanna Squeglia, Lindsay M. Infante, M. Alejandra Bava, Sunita Tapert, Susan F. Brain Sci Article Characterizing the effects of alcohol and marijuana use on adolescent brain development is important for understanding potential alterations in neurodevelopment. Several cross sectional studies have identified group differences in white matter integrity after initiation of heavy alcohol and marijuana use, however none have explored white matter trajectories in adolescents pre- and post initiation of use, particularly for marijuana users. This study followed 16 adolescents with minimal alcohol and marijuana use at ages 16–18 over three years. At follow-up, teens were 19–22 years old; half of the participants initiated heavy alcohol use and half initiated heavy alcohol and marijuana use. Repeated-measures ANOVA revealed 20 clusters in association and projection fibers tracts (p < 0.01) in which a group by time interaction was found. Most consistently, white matter integrity (i.e., fractional anisotropy) decreased for those who initiated both heavy alcohol and marijuana use over the follow-up interval. No effect of time or change in white matter integrity was seen for those who initiated alcohol use only in the majority of clusters. In most regions, at the baseline time point, teens who would later initiate both alcohol and marijuana use demonstrated white matter integrity greater than or equal to teens that initiated alcohol use only. Findings suggest poorer tissue integrity associated with combined initiation of heavy alcohol and marijuana use in late adolescence. While pre-existing differences may also be related to likelihood of substance use, the present data suggest an effect on tissue integrity for these teens transitioning to combined alcohol and marijuana use in later adolescence. MDPI 2013-03-22 /pmc/articles/PMC3728679/ /pubmed/23914300 http://dx.doi.org/10.3390/brainsci3010396 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Jacobus, Joanna
Squeglia, Lindsay M.
Infante, M. Alejandra
Bava, Sunita
Tapert, Susan F.
White Matter Integrity Pre- and Post Marijuana and Alcohol Initiation in Adolescence
title White Matter Integrity Pre- and Post Marijuana and Alcohol Initiation in Adolescence
title_full White Matter Integrity Pre- and Post Marijuana and Alcohol Initiation in Adolescence
title_fullStr White Matter Integrity Pre- and Post Marijuana and Alcohol Initiation in Adolescence
title_full_unstemmed White Matter Integrity Pre- and Post Marijuana and Alcohol Initiation in Adolescence
title_short White Matter Integrity Pre- and Post Marijuana and Alcohol Initiation in Adolescence
title_sort white matter integrity pre- and post marijuana and alcohol initiation in adolescence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728679/
https://www.ncbi.nlm.nih.gov/pubmed/23914300
http://dx.doi.org/10.3390/brainsci3010396
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