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Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family

Calcium (Ca(2+)) is a universal second messenger that regulates a number of diverse cellular processes including cell proliferation, development, motility, secretion, learning and memory1, 2. A variety of stimuli, such as hormones, growth factors, cytokines, and neurotransmitters induce changes in t...

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Detalles Bibliográficos
Autores principales: Rusciano, M.R., Maione, A.S., Illario, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università di Salerno 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728794/
https://www.ncbi.nlm.nih.gov/pubmed/23905065
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author Rusciano, M.R.
Maione, A.S.
Illario, M.
author_facet Rusciano, M.R.
Maione, A.S.
Illario, M.
author_sort Rusciano, M.R.
collection PubMed
description Calcium (Ca(2+)) is a universal second messenger that regulates a number of diverse cellular processes including cell proliferation, development, motility, secretion, learning and memory1, 2. A variety of stimuli, such as hormones, growth factors, cytokines, and neurotransmitters induce changes in the intracellular levels of Ca(2+). The most ubiquitous and abundant protein that serves as a receptor to sense changes in Ca(2+) concentrations is Calmodulin (CaM), thus mediating the role as second messenger of this ion. The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cell functions. Among the many Ca(2+)/CaM binding proteins, the multifunctional protein kinases CaMKII and CaMKIV play pivotal roles in the cell.
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spelling pubmed-37287942013-07-31 Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family Rusciano, M.R. Maione, A.S. Illario, M. Transl Med UniSa Review Calcium (Ca(2+)) is a universal second messenger that regulates a number of diverse cellular processes including cell proliferation, development, motility, secretion, learning and memory1, 2. A variety of stimuli, such as hormones, growth factors, cytokines, and neurotransmitters induce changes in the intracellular levels of Ca(2+). The most ubiquitous and abundant protein that serves as a receptor to sense changes in Ca(2+) concentrations is Calmodulin (CaM), thus mediating the role as second messenger of this ion. The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cell functions. Among the many Ca(2+)/CaM binding proteins, the multifunctional protein kinases CaMKII and CaMKIV play pivotal roles in the cell. Università di Salerno 2012-10-11 /pmc/articles/PMC3728794/ /pubmed/23905065 Text en http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Rusciano, M.R.
Maione, A.S.
Illario, M.
Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family
title Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family
title_full Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family
title_fullStr Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family
title_full_unstemmed Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family
title_short Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family
title_sort sisters acts: converging signaling between camkii and camkiv, two members of the same family
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728794/
https://www.ncbi.nlm.nih.gov/pubmed/23905065
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