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Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs
PURPOSE: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND METHODS: review of literature and elaboration of a hypothesis, design of an experimental method. RESULTS: recent clinical studies were conducte...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Università di Salerno
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728795/ https://www.ncbi.nlm.nih.gov/pubmed/23905064 |
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author | Piazza, O Romano, R Scarpati, G Esposito, C Cavaglià, E Corona, M |
author_facet | Piazza, O Romano, R Scarpati, G Esposito, C Cavaglià, E Corona, M |
author_sort | Piazza, O |
collection | PubMed |
description | PURPOSE: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND METHODS: review of literature and elaboration of a hypothesis, design of an experimental method. RESULTS: recent clinical studies were conducted by withdrawing cirrhotic patients’ blood from right hepatic vein during hepatic vein pressure gradient measurements. Basing on our personal clinical experience and evaluation of research needs, an experimental model is proposed. CONCLUSIONS: contemporary measurement of peripheral and hepatic concentration of drugs by peripheral vein and hepatic vein catheterization can be used to create a reliable and reproducible porcine model to study liver metabolism of drugs in vivo. |
format | Online Article Text |
id | pubmed-3728795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Università di Salerno |
record_format | MEDLINE/PubMed |
spelling | pubmed-37287952013-07-31 Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs Piazza, O Romano, R Scarpati, G Esposito, C Cavaglià, E Corona, M Transl Med UniSa Research Paper PURPOSE: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND METHODS: review of literature and elaboration of a hypothesis, design of an experimental method. RESULTS: recent clinical studies were conducted by withdrawing cirrhotic patients’ blood from right hepatic vein during hepatic vein pressure gradient measurements. Basing on our personal clinical experience and evaluation of research needs, an experimental model is proposed. CONCLUSIONS: contemporary measurement of peripheral and hepatic concentration of drugs by peripheral vein and hepatic vein catheterization can be used to create a reliable and reproducible porcine model to study liver metabolism of drugs in vivo. Università di Salerno 2012-10-11 /pmc/articles/PMC3728795/ /pubmed/23905064 Text en http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Piazza, O Romano, R Scarpati, G Esposito, C Cavaglià, E Corona, M Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs |
title | Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs |
title_full | Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs |
title_fullStr | Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs |
title_full_unstemmed | Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs |
title_short | Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs |
title_sort | minimally invasive swine experimental model for the in vivo study of liver metabolism of drugs |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728795/ https://www.ncbi.nlm.nih.gov/pubmed/23905064 |
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