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Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs

PURPOSE: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND METHODS: review of literature and elaboration of a hypothesis, design of an experimental method. RESULTS: recent clinical studies were conducte...

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Autores principales: Piazza, O, Romano, R, Scarpati, G, Esposito, C, Cavaglià, E, Corona, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università di Salerno 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728795/
https://www.ncbi.nlm.nih.gov/pubmed/23905064
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author Piazza, O
Romano, R
Scarpati, G
Esposito, C
Cavaglià, E
Corona, M
author_facet Piazza, O
Romano, R
Scarpati, G
Esposito, C
Cavaglià, E
Corona, M
author_sort Piazza, O
collection PubMed
description PURPOSE: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND METHODS: review of literature and elaboration of a hypothesis, design of an experimental method. RESULTS: recent clinical studies were conducted by withdrawing cirrhotic patients’ blood from right hepatic vein during hepatic vein pressure gradient measurements. Basing on our personal clinical experience and evaluation of research needs, an experimental model is proposed. CONCLUSIONS: contemporary measurement of peripheral and hepatic concentration of drugs by peripheral vein and hepatic vein catheterization can be used to create a reliable and reproducible porcine model to study liver metabolism of drugs in vivo.
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spelling pubmed-37287952013-07-31 Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs Piazza, O Romano, R Scarpati, G Esposito, C Cavaglià, E Corona, M Transl Med UniSa Research Paper PURPOSE: To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND METHODS: review of literature and elaboration of a hypothesis, design of an experimental method. RESULTS: recent clinical studies were conducted by withdrawing cirrhotic patients’ blood from right hepatic vein during hepatic vein pressure gradient measurements. Basing on our personal clinical experience and evaluation of research needs, an experimental model is proposed. CONCLUSIONS: contemporary measurement of peripheral and hepatic concentration of drugs by peripheral vein and hepatic vein catheterization can be used to create a reliable and reproducible porcine model to study liver metabolism of drugs in vivo. Università di Salerno 2012-10-11 /pmc/articles/PMC3728795/ /pubmed/23905064 Text en http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Piazza, O
Romano, R
Scarpati, G
Esposito, C
Cavaglià, E
Corona, M
Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs
title Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs
title_full Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs
title_fullStr Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs
title_full_unstemmed Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs
title_short Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs
title_sort minimally invasive swine experimental model for the in vivo study of liver metabolism of drugs
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728795/
https://www.ncbi.nlm.nih.gov/pubmed/23905064
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