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Risk Factors and Primary Prevention Trials for Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease resulting in the designated immune destruction of insulin producing β-cells, usually diagnosed in youth, and associated with important psychological, familial, and social disorders. Once diagnosed, patients need lifelong insulin treatme...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729009/ https://www.ncbi.nlm.nih.gov/pubmed/23904791 http://dx.doi.org/10.7150/ijbs.6610 |
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author | Wu, Yan-Ling Ding, Yan-Ping Gao, Jian Tanaka, Yoshimasa Zhang, Wen |
author_facet | Wu, Yan-Ling Ding, Yan-Ping Gao, Jian Tanaka, Yoshimasa Zhang, Wen |
author_sort | Wu, Yan-Ling |
collection | PubMed |
description | Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease resulting in the designated immune destruction of insulin producing β-cells, usually diagnosed in youth, and associated with important psychological, familial, and social disorders. Once diagnosed, patients need lifelong insulin treatment and will experience multiple disease-associated complications. There is no cure for T1DM currently. The last decade has witnessed great progress in elucidating the causes and treatment of the disease based on numerous researches both in rodent models of spontaneous diabetes and in humans. This article summarises our current understanding of the pathogenesis of T1DM, the roles of the immune system, genes, environment and other factors in the continuing and rapid increase in T1DM incidence at younger ages in humans. In addition, we discuss the strategies for primary and secondary prevention trials of T1DM. The purpose of this review is to provide an overview of this disorder's pathogenesis, risk factors that cause the disease, as well as to bring forward an ideal approach to prevent and cure the disorder. |
format | Online Article Text |
id | pubmed-3729009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-37290092013-07-31 Risk Factors and Primary Prevention Trials for Type 1 Diabetes Wu, Yan-Ling Ding, Yan-Ping Gao, Jian Tanaka, Yoshimasa Zhang, Wen Int J Biol Sci Research Paper Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease resulting in the designated immune destruction of insulin producing β-cells, usually diagnosed in youth, and associated with important psychological, familial, and social disorders. Once diagnosed, patients need lifelong insulin treatment and will experience multiple disease-associated complications. There is no cure for T1DM currently. The last decade has witnessed great progress in elucidating the causes and treatment of the disease based on numerous researches both in rodent models of spontaneous diabetes and in humans. This article summarises our current understanding of the pathogenesis of T1DM, the roles of the immune system, genes, environment and other factors in the continuing and rapid increase in T1DM incidence at younger ages in humans. In addition, we discuss the strategies for primary and secondary prevention trials of T1DM. The purpose of this review is to provide an overview of this disorder's pathogenesis, risk factors that cause the disease, as well as to bring forward an ideal approach to prevent and cure the disorder. Ivyspring International Publisher 2013-07-18 /pmc/articles/PMC3729009/ /pubmed/23904791 http://dx.doi.org/10.7150/ijbs.6610 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Research Paper Wu, Yan-Ling Ding, Yan-Ping Gao, Jian Tanaka, Yoshimasa Zhang, Wen Risk Factors and Primary Prevention Trials for Type 1 Diabetes |
title | Risk Factors and Primary Prevention Trials for Type 1 Diabetes |
title_full | Risk Factors and Primary Prevention Trials for Type 1 Diabetes |
title_fullStr | Risk Factors and Primary Prevention Trials for Type 1 Diabetes |
title_full_unstemmed | Risk Factors and Primary Prevention Trials for Type 1 Diabetes |
title_short | Risk Factors and Primary Prevention Trials for Type 1 Diabetes |
title_sort | risk factors and primary prevention trials for type 1 diabetes |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729009/ https://www.ncbi.nlm.nih.gov/pubmed/23904791 http://dx.doi.org/10.7150/ijbs.6610 |
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