Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies

We report a new model to project the predictive performance of polygenic models based on the number and distribution of effect sizes for the underlying susceptibility alleles and the size of the training dataset. Using estimates of effect-size distribution and heritability derived from current studi...

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Detalles Bibliográficos
Autores principales: Chatterjee, Nilanjan, Wheeler, Bill, Sampson, Joshua, Hartge, Patricia, Chanock, Stephen J., Park, Ju-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729116/
https://www.ncbi.nlm.nih.gov/pubmed/23455638
http://dx.doi.org/10.1038/ng.2579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729116/
https://www.ncbi.nlm.nih.gov/pubmed/23455638
http://dx.doi.org/10.1038/ng.2579

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