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Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†)

We combined quantitative relaxation rate (R(1)= 1/T(1)) mapping—to measure local myelination—with fMRI-based retinotopy. Gray–white and pial surfaces were reconstructed and used to sample R(1) at different cortical depths. Like myelination, R(1) decreased from deeper to superficial layers. R(1) decr...

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Detalles Bibliográficos
Autores principales: Sereno, Martin I., Lutti, Antoine, Weiskopf, Nikolaus, Dick, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729202/
https://www.ncbi.nlm.nih.gov/pubmed/22826609
http://dx.doi.org/10.1093/cercor/bhs213
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author Sereno, Martin I.
Lutti, Antoine
Weiskopf, Nikolaus
Dick, Frederic
author_facet Sereno, Martin I.
Lutti, Antoine
Weiskopf, Nikolaus
Dick, Frederic
author_sort Sereno, Martin I.
collection PubMed
description We combined quantitative relaxation rate (R(1)= 1/T(1)) mapping—to measure local myelination—with fMRI-based retinotopy. Gray–white and pial surfaces were reconstructed and used to sample R(1) at different cortical depths. Like myelination, R(1) decreased from deeper to superficial layers. R(1) decreased passing from V1 and MT, to immediately surrounding areas, then to the angular gyrus. High R(1) was correlated across the cortex with convex local curvature so the data was first “de-curved”. By overlaying R(1) and retinotopic maps, we found that many visual area borders were associated with significant R(1) increases including V1, V3A, MT, V6, V6A, V8/VO1, FST, and VIP. Surprisingly, retinotopic MT occupied only the posterior portion of an oval-shaped lateral occipital R(1) maximum. R(1) maps were reproducible within individuals and comparable between subjects without intensity normalization, enabling multi-center studies of development, aging, and disease progression, and structure/function mapping in other modalities.
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spelling pubmed-37292022013-07-31 Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†) Sereno, Martin I. Lutti, Antoine Weiskopf, Nikolaus Dick, Frederic Cereb Cortex Articles We combined quantitative relaxation rate (R(1)= 1/T(1)) mapping—to measure local myelination—with fMRI-based retinotopy. Gray–white and pial surfaces were reconstructed and used to sample R(1) at different cortical depths. Like myelination, R(1) decreased from deeper to superficial layers. R(1) decreased passing from V1 and MT, to immediately surrounding areas, then to the angular gyrus. High R(1) was correlated across the cortex with convex local curvature so the data was first “de-curved”. By overlaying R(1) and retinotopic maps, we found that many visual area borders were associated with significant R(1) increases including V1, V3A, MT, V6, V6A, V8/VO1, FST, and VIP. Surprisingly, retinotopic MT occupied only the posterior portion of an oval-shaped lateral occipital R(1) maximum. R(1) maps were reproducible within individuals and comparable between subjects without intensity normalization, enabling multi-center studies of development, aging, and disease progression, and structure/function mapping in other modalities. Oxford University Press 2013-09 2012-07-23 /pmc/articles/PMC3729202/ /pubmed/22826609 http://dx.doi.org/10.1093/cercor/bhs213 Text en © The Author 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Sereno, Martin I.
Lutti, Antoine
Weiskopf, Nikolaus
Dick, Frederic
Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†)
title Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†)
title_full Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†)
title_fullStr Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†)
title_full_unstemmed Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†)
title_short Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†)
title_sort mapping the human cortical surface by combining quantitative t(1) with retinotopy(†)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729202/
https://www.ncbi.nlm.nih.gov/pubmed/22826609
http://dx.doi.org/10.1093/cercor/bhs213
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