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Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†)
We combined quantitative relaxation rate (R(1)= 1/T(1)) mapping—to measure local myelination—with fMRI-based retinotopy. Gray–white and pial surfaces were reconstructed and used to sample R(1) at different cortical depths. Like myelination, R(1) decreased from deeper to superficial layers. R(1) decr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729202/ https://www.ncbi.nlm.nih.gov/pubmed/22826609 http://dx.doi.org/10.1093/cercor/bhs213 |
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author | Sereno, Martin I. Lutti, Antoine Weiskopf, Nikolaus Dick, Frederic |
author_facet | Sereno, Martin I. Lutti, Antoine Weiskopf, Nikolaus Dick, Frederic |
author_sort | Sereno, Martin I. |
collection | PubMed |
description | We combined quantitative relaxation rate (R(1)= 1/T(1)) mapping—to measure local myelination—with fMRI-based retinotopy. Gray–white and pial surfaces were reconstructed and used to sample R(1) at different cortical depths. Like myelination, R(1) decreased from deeper to superficial layers. R(1) decreased passing from V1 and MT, to immediately surrounding areas, then to the angular gyrus. High R(1) was correlated across the cortex with convex local curvature so the data was first “de-curved”. By overlaying R(1) and retinotopic maps, we found that many visual area borders were associated with significant R(1) increases including V1, V3A, MT, V6, V6A, V8/VO1, FST, and VIP. Surprisingly, retinotopic MT occupied only the posterior portion of an oval-shaped lateral occipital R(1) maximum. R(1) maps were reproducible within individuals and comparable between subjects without intensity normalization, enabling multi-center studies of development, aging, and disease progression, and structure/function mapping in other modalities. |
format | Online Article Text |
id | pubmed-3729202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-37292022013-07-31 Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†) Sereno, Martin I. Lutti, Antoine Weiskopf, Nikolaus Dick, Frederic Cereb Cortex Articles We combined quantitative relaxation rate (R(1)= 1/T(1)) mapping—to measure local myelination—with fMRI-based retinotopy. Gray–white and pial surfaces were reconstructed and used to sample R(1) at different cortical depths. Like myelination, R(1) decreased from deeper to superficial layers. R(1) decreased passing from V1 and MT, to immediately surrounding areas, then to the angular gyrus. High R(1) was correlated across the cortex with convex local curvature so the data was first “de-curved”. By overlaying R(1) and retinotopic maps, we found that many visual area borders were associated with significant R(1) increases including V1, V3A, MT, V6, V6A, V8/VO1, FST, and VIP. Surprisingly, retinotopic MT occupied only the posterior portion of an oval-shaped lateral occipital R(1) maximum. R(1) maps were reproducible within individuals and comparable between subjects without intensity normalization, enabling multi-center studies of development, aging, and disease progression, and structure/function mapping in other modalities. Oxford University Press 2013-09 2012-07-23 /pmc/articles/PMC3729202/ /pubmed/22826609 http://dx.doi.org/10.1093/cercor/bhs213 Text en © The Author 2012. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Sereno, Martin I. Lutti, Antoine Weiskopf, Nikolaus Dick, Frederic Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†) |
title | Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†) |
title_full | Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†) |
title_fullStr | Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†) |
title_full_unstemmed | Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†) |
title_short | Mapping the Human Cortical Surface by Combining Quantitative T(1) with Retinotopy(†) |
title_sort | mapping the human cortical surface by combining quantitative t(1) with retinotopy(†) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729202/ https://www.ncbi.nlm.nih.gov/pubmed/22826609 http://dx.doi.org/10.1093/cercor/bhs213 |
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