Cargando…

A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington’s disease

Apathy, characterized by generally reduced interest in and likelihood to perform goal-directed actions, is a recognized symptom of Huntington’s disease (HD), a devastating neurological disorder caused by a CAG repeat expansion of the Htt gene located on chromosome 4. The present experiments used a m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oakeshott, Stephen, Port, Russell, Cummins-Sutphen, Jane, Berger, Jason, Watson-Johnson, Judy, Ramboz, Sylvie, Paterson, Neil, Kwak, Seung, Howland, David, Brunner, Dani
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	HD Models
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729251/ https://www.ncbi.nlm.nih.gov/pubmed/23925262 http://dx.doi.org/10.1371/4f972cffe82c0

Ejemplares similares

Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington’s Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits
por: Kudwa, Andrea E., et al.
Publicado: (2013)

Deficits in a Simple Visual Go/No-go Discrimination Task in Two Mouse Models of Huntington’s Disease
por: Oakeshott, Stephen, et al.
Publicado: (2013)

High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease
por: Balci, Fuat, et al.
Publicado: (2013)

Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington’s disease
por: Landles, Christian, et al.
Publicado: (2012)

Pitfalls in the detection of cholesterol in Huntington’s disease models
por: Marullo, Manuela, et al.
Publicado: (2012)

Dysfunctional mitochondrial respiration in the striatum of the Huntington’s disease transgenic R6/2 mouse model
por: Aidt, Frederik Heurlin, et al.
Publicado: (2013)

Characterization of Striatal Neuronal Loss and Atrophy in the R6/2 Mouse Model of Huntington’s Disease
por: Dodds, Lindsay, et al.
Publicado: (2014)

Differential Synaptic and Extrasynaptic Glutamate-Receptor Alterations in Striatal Medium-Sized Spiny Neurons of Aged YAC128 Huntington’s Disease Mice
por: Botelho, Eliã P., et al.
Publicado: (2014)

Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease
por: Sadan, Ofer, et al.
Publicado: (2012)

Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD
por: Curtin, Paul C. P., et al.
Publicado: (2016)

HD mouse models reveal clear deficits in learning to perform a simple instrumental response
por: Oakeshott, Stephen, et al.
Publicado: (2011)

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
por: Menalled, Liliana B., et al.
Publicado: (2012)

Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease
por: Oakeshott, Stephen, et al.
Publicado: (2011)

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease
por: Menalled, Liliana B., et al.
Publicado: (2014)

Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020)

Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175(+/−) Mouse Model of Huntington's Disease
por: Lim, Sean Austin O., et al.
Publicado: (2021)

Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay
por: Papadopoulou, Aikaterini S., et al.
Publicado: (2019)

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
por: Sanchis, Ana, et al.
Publicado: (2019)

The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models
por: Speziale, Roberto, et al.
Publicado: (2023)

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
por: Heikkinen, Taneli, et al.
Publicado: (2012)

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum
por: Pinchaud, Katleen, et al.
Publicado: (2023)

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice
por: Schindler, Franziska, et al.
Publicado: (2021)

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2016)

Improved synthesis of [(18)F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors
por: Huhtala, Tuulia, et al.
Publicado: (2019)

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
por: Carty, Nikisha, et al.
Publicado: (2015)

Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice
por: Li, Si Han, et al.
Publicado: (2022)

Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
por: Adhikari, Mohit H., et al.
Publicado: (2023)

Small Molecule Pytren-4QMn Metal Complex Slows down Huntington’s Disease Progression in Male zQ175 Transgenic Mice
por: Merino, Marián, et al.
Publicado: (2023)

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2019)

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches
por: Smith, Edward J, et al.
Publicado: (2023)

Search for t to Zq
por: CMS Collaboration
Publicado: (2012)

Huntingtin Co-Isolates with Small Extracellular Vesicles from Blood Plasma of TgHD and KI-HD Pig Models of Huntington’s Disease and Human Blood Plasma
por: Ananbeh, Hanadi, et al.
Publicado: (2022)

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease
por: Wang, Huei-Bin, et al.
Publicado: (2018)

Marginal hazard ratio estimates in joint frailty models for heart failure trials
por: Toenges, Gerrit, et al.
Publicado: (2019)

Vitamin A Absorption Determined in Rats Using a Plasma Isotope Ratio Method
por: Green, Michael H, et al.
Publicado: (2020)

A statistical model for the dynamics of COVID‐19 infections and their case detection ratio in 2020
por: Schneble, Marc, et al.
Publicado: (2021)

Assessment of Depression, Anxiety and Apathy in Prodromal and Early Huntington Disease
por: Vaccarino, Anthony L, et al.
Publicado: (2011)

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease
por: Cutler, Tamara S., et al.
Publicado: (2017)

Disease Burden of Huntington’s Disease (HD) on People Living with HD and Care Partners in Canada
por: Shaw, Eileen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0ng6m6d8lcfcd1kmo6an6bmtbl