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Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age
Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational age between PE women and healthy pregnant controls. This may pose a potentia...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729459/ https://www.ncbi.nlm.nih.gov/pubmed/23936112 http://dx.doi.org/10.1371/journal.pone.0069848 |
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author | Lian, Ingrid A. Langaas, Mette Moses, Eric Johansson, Åsa |
author_facet | Lian, Ingrid A. Langaas, Mette Moses, Eric Johansson, Åsa |
author_sort | Lian, Ingrid A. |
collection | PubMed |
description | Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational age between PE women and healthy pregnant controls. This may pose a potential bias since gestational age has been shown to dramatically influence gene expression in utero-placental tissue. By pooling data from three genome-wide transcription studies of the maternal-fetal interface, we have evaluated the relative effect of gestational age and PE on gene expression. A total of 18,180 transcripts were evaluated in 49 PE cases and 105 controls, with gestational age ranging from week 14 to 42. A total of 22 transcripts were associated with PE, whereas 92 transcripts with gestational age (nominal P value <1.51*10(−6), Bonferroni adjusted P value <0.05). Our results indicate that gestational age has a great influence on gene expression both in normal and PE-complicated pregnancies. This effect might introduce serious bias in data analyses and needs to be carefully assessed in future genome-wide transcription studies. |
format | Online Article Text |
id | pubmed-3729459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37294592013-08-09 Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age Lian, Ingrid A. Langaas, Mette Moses, Eric Johansson, Åsa PLoS One Research Article Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational age between PE women and healthy pregnant controls. This may pose a potential bias since gestational age has been shown to dramatically influence gene expression in utero-placental tissue. By pooling data from three genome-wide transcription studies of the maternal-fetal interface, we have evaluated the relative effect of gestational age and PE on gene expression. A total of 18,180 transcripts were evaluated in 49 PE cases and 105 controls, with gestational age ranging from week 14 to 42. A total of 22 transcripts were associated with PE, whereas 92 transcripts with gestational age (nominal P value <1.51*10(−6), Bonferroni adjusted P value <0.05). Our results indicate that gestational age has a great influence on gene expression both in normal and PE-complicated pregnancies. This effect might introduce serious bias in data analyses and needs to be carefully assessed in future genome-wide transcription studies. Public Library of Science 2013-07-31 /pmc/articles/PMC3729459/ /pubmed/23936112 http://dx.doi.org/10.1371/journal.pone.0069848 Text en © 2013 Lian et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Lian, Ingrid A. Langaas, Mette Moses, Eric Johansson, Åsa Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
title | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
title_full | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
title_fullStr | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
title_full_unstemmed | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
title_short | Differential Gene Expression at the Maternal-Fetal Interface in Preeclampsia Is Influenced by Gestational Age |
title_sort | differential gene expression at the maternal-fetal interface in preeclampsia is influenced by gestational age |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729459/ https://www.ncbi.nlm.nih.gov/pubmed/23936112 http://dx.doi.org/10.1371/journal.pone.0069848 |
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