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Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery

PURPOSE: To investigate the analgesic effect and incidence of postoperative nausea and vomiting (PONV) between the opioid fentanyl and the non-steroidal anti-inflammatory drug ketorolac in patients who underwent eye amputation surgery. METHODS: Retrospective observational case series. Eighty-two pat...

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Autores principales: Kim, Jin Hyung, Jang, Sun Young, Kim, Myung Jin, Lee, Sang Yeul, Yoon, Jin Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Ophthalmological Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730063/
https://www.ncbi.nlm.nih.gov/pubmed/23908567
http://dx.doi.org/10.3341/kjo.2013.27.4.229
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author Kim, Jin Hyung
Jang, Sun Young
Kim, Myung Jin
Lee, Sang Yeul
Yoon, Jin Sook
author_facet Kim, Jin Hyung
Jang, Sun Young
Kim, Myung Jin
Lee, Sang Yeul
Yoon, Jin Sook
author_sort Kim, Jin Hyung
collection PubMed
description PURPOSE: To investigate the analgesic effect and incidence of postoperative nausea and vomiting (PONV) between the opioid fentanyl and the non-steroidal anti-inflammatory drug ketorolac in patients who underwent eye amputation surgery. METHODS: Retrospective observational case series. Eighty-two patients underwent evisceration or enucleation surgery by one surgeon over a 2-year period. Fentanyl by intravenous patient-controlled analgesia (IV-PCA) at 20 µg/kg with 12 mg/kg ondansetron or intravenous ketorolac at 2 mg/kg/day was administered to patients at postoperative days 0, 1, and 2. The pain score was measured using an 11-point visual analog scale (VAS). The incidence of severe nausea requiring anti-emetics and the incidence of vomiting were reviewed. RESULTS: The mean postoperative VAS in the fentanyl group was significantly lower than that in the ketorolac group on the day of operation for both types of surgery (p = 0.001 and p = 0.004, respectively). At postoperative days 1 and 2, the mean VAS was not different between the two groups for either surgical type (p > 0.05 for both days). The mean VAS was significantly higher in eviscerated patients than in enucleated patients at postoperative days 0 and 1 in the fentanyl group (p = 0.023 and p = 0.016, respectively). However, this was not observed in the ketorolac group. The incidence of PONV was higher in the fentanyl group than in the ketorolac group, although this was not statistically significant for either surgical type (p > 0.05 for both groups). CONCLUSIONS: Fentanyl was more effective as an analgesic than was ketorolac on the day of operation for both surgical types. There was no difference between the two analgesics on postoperative day 1. The analgesic effect of fentanyl in enucleated patients was significantly higher than in eviscerated patients at postoperative days 0 and 1. The use of fentanyl by IV-PCA was associated with greater PONV despite co-administration with anti-emetics, although this finding was not significant.
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spelling pubmed-37300632013-08-01 Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery Kim, Jin Hyung Jang, Sun Young Kim, Myung Jin Lee, Sang Yeul Yoon, Jin Sook Korean J Ophthalmol Original Article PURPOSE: To investigate the analgesic effect and incidence of postoperative nausea and vomiting (PONV) between the opioid fentanyl and the non-steroidal anti-inflammatory drug ketorolac in patients who underwent eye amputation surgery. METHODS: Retrospective observational case series. Eighty-two patients underwent evisceration or enucleation surgery by one surgeon over a 2-year period. Fentanyl by intravenous patient-controlled analgesia (IV-PCA) at 20 µg/kg with 12 mg/kg ondansetron or intravenous ketorolac at 2 mg/kg/day was administered to patients at postoperative days 0, 1, and 2. The pain score was measured using an 11-point visual analog scale (VAS). The incidence of severe nausea requiring anti-emetics and the incidence of vomiting were reviewed. RESULTS: The mean postoperative VAS in the fentanyl group was significantly lower than that in the ketorolac group on the day of operation for both types of surgery (p = 0.001 and p = 0.004, respectively). At postoperative days 1 and 2, the mean VAS was not different between the two groups for either surgical type (p > 0.05 for both days). The mean VAS was significantly higher in eviscerated patients than in enucleated patients at postoperative days 0 and 1 in the fentanyl group (p = 0.023 and p = 0.016, respectively). However, this was not observed in the ketorolac group. The incidence of PONV was higher in the fentanyl group than in the ketorolac group, although this was not statistically significant for either surgical type (p > 0.05 for both groups). CONCLUSIONS: Fentanyl was more effective as an analgesic than was ketorolac on the day of operation for both surgical types. There was no difference between the two analgesics on postoperative day 1. The analgesic effect of fentanyl in enucleated patients was significantly higher than in eviscerated patients at postoperative days 0 and 1. The use of fentanyl by IV-PCA was associated with greater PONV despite co-administration with anti-emetics, although this finding was not significant. The Korean Ophthalmological Society 2013-08 2013-07-18 /pmc/articles/PMC3730063/ /pubmed/23908567 http://dx.doi.org/10.3341/kjo.2013.27.4.229 Text en © 2013 The Korean Ophthalmological Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jin Hyung
Jang, Sun Young
Kim, Myung Jin
Lee, Sang Yeul
Yoon, Jin Sook
Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery
title Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery
title_full Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery
title_fullStr Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery
title_full_unstemmed Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery
title_short Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery
title_sort comparison of pain-relieving effects of fentanyl versus ketorolac after eye amputation surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730063/
https://www.ncbi.nlm.nih.gov/pubmed/23908567
http://dx.doi.org/10.3341/kjo.2013.27.4.229
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