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Metabolic Factors and Chronic Hepatitis C: A Complex Interplay

In the last years, several lines of evidence showed how metabolic factors may influence the natural history of patients with chronic hepatitis C. Chronic HCV infection is able to perturb the metabolic homeostasis of the host, in a context of complex interactions where pre-existent metabolic status a...

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Autores principales: Macaluso, Fabio Salvatore, Maida, Marcello, Minissale, Maria Giovanna, Li Vigni, Teresa, Attardo, Simona, Orlando, Emanuele, Petta, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730187/
https://www.ncbi.nlm.nih.gov/pubmed/23956991
http://dx.doi.org/10.1155/2013/564645
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author Macaluso, Fabio Salvatore
Maida, Marcello
Minissale, Maria Giovanna
Li Vigni, Teresa
Attardo, Simona
Orlando, Emanuele
Petta, Salvatore
author_facet Macaluso, Fabio Salvatore
Maida, Marcello
Minissale, Maria Giovanna
Li Vigni, Teresa
Attardo, Simona
Orlando, Emanuele
Petta, Salvatore
author_sort Macaluso, Fabio Salvatore
collection PubMed
description In the last years, several lines of evidence showed how metabolic factors may influence the natural history of patients with chronic hepatitis C. Chronic HCV infection is able to perturb the metabolic homeostasis of the host, in a context of complex interactions where pre-existent metabolic status and genetic background play an important role, allowing us to state that HCV infection is a systemic disease. In this review, we discuss the most recent lines of evidence on the main metabolic factors that are known to be associated with CHC, namely, insulin resistance/type 2 diabetes, steatosis, visceral obesity, atherosclerosis, vitamin D, menopause, fructose and coffee intake, lipoproteins, methylenetetrahydrofolate reductase status, and hyperuricaemia. In particular, we focus on the pathophysiological mechanisms underlying the correlation between HCV infection and metabolic disorders, the impact of metabolic factors on the progression of liver and non-liver-related diseases, and, on the contrary, the possible influence of chronic HCV infection on metabolic features. In this setting, the importance of a multifaceted evaluation of CHC patients and a prompt correction of modifiable metabolic risk factors should be emphasized.
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spelling pubmed-37301872013-08-16 Metabolic Factors and Chronic Hepatitis C: A Complex Interplay Macaluso, Fabio Salvatore Maida, Marcello Minissale, Maria Giovanna Li Vigni, Teresa Attardo, Simona Orlando, Emanuele Petta, Salvatore Biomed Res Int Review Article In the last years, several lines of evidence showed how metabolic factors may influence the natural history of patients with chronic hepatitis C. Chronic HCV infection is able to perturb the metabolic homeostasis of the host, in a context of complex interactions where pre-existent metabolic status and genetic background play an important role, allowing us to state that HCV infection is a systemic disease. In this review, we discuss the most recent lines of evidence on the main metabolic factors that are known to be associated with CHC, namely, insulin resistance/type 2 diabetes, steatosis, visceral obesity, atherosclerosis, vitamin D, menopause, fructose and coffee intake, lipoproteins, methylenetetrahydrofolate reductase status, and hyperuricaemia. In particular, we focus on the pathophysiological mechanisms underlying the correlation between HCV infection and metabolic disorders, the impact of metabolic factors on the progression of liver and non-liver-related diseases, and, on the contrary, the possible influence of chronic HCV infection on metabolic features. In this setting, the importance of a multifaceted evaluation of CHC patients and a prompt correction of modifiable metabolic risk factors should be emphasized. Hindawi Publishing Corporation 2013 2013-07-17 /pmc/articles/PMC3730187/ /pubmed/23956991 http://dx.doi.org/10.1155/2013/564645 Text en Copyright © 2013 Fabio Salvatore Macaluso et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Macaluso, Fabio Salvatore
Maida, Marcello
Minissale, Maria Giovanna
Li Vigni, Teresa
Attardo, Simona
Orlando, Emanuele
Petta, Salvatore
Metabolic Factors and Chronic Hepatitis C: A Complex Interplay
title Metabolic Factors and Chronic Hepatitis C: A Complex Interplay
title_full Metabolic Factors and Chronic Hepatitis C: A Complex Interplay
title_fullStr Metabolic Factors and Chronic Hepatitis C: A Complex Interplay
title_full_unstemmed Metabolic Factors and Chronic Hepatitis C: A Complex Interplay
title_short Metabolic Factors and Chronic Hepatitis C: A Complex Interplay
title_sort metabolic factors and chronic hepatitis c: a complex interplay
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730187/
https://www.ncbi.nlm.nih.gov/pubmed/23956991
http://dx.doi.org/10.1155/2013/564645
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