Non-replicating rhabdovirus-derived particles (NRRPs) eradicate acute leukemia by direct cytolysis and induction of antitumor immunity

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Rhabdoviruses (RVs) are currently being pursued as anticancer therapeutics for various tumor types, notably leukemia. However, modest virion production and limited spread between noncontiguous circulating leukemic cells requires high-dose administration of RVs, which exceeds the maximum tolerable do...

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Detalles Bibliográficos
Autores principales: Batenchuk, C, Le Boeuf, F, Stubbert, L, Falls, T, Atkins, H L, Bell, J C, Conrad, D P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730201/
https://www.ncbi.nlm.nih.gov/pubmed/23852158
http://dx.doi.org/10.1038/bcj.2013.23
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