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Lessons from next-generation sequencing analysis in hematological malignancies
Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730204/ https://www.ncbi.nlm.nih.gov/pubmed/23872706 http://dx.doi.org/10.1038/bcj.2013.26 |
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author | Braggio, E Egan, J B Fonseca, R Stewart, A K |
author_facet | Braggio, E Egan, J B Fonseca, R Stewart, A K |
author_sort | Braggio, E |
collection | PubMed |
description | Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis. |
format | Online Article Text |
id | pubmed-3730204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-37302042013-08-01 Lessons from next-generation sequencing analysis in hematological malignancies Braggio, E Egan, J B Fonseca, R Stewart, A K Blood Cancer J Review Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis. Nature Publishing Group 2013-07 2013-07-19 /pmc/articles/PMC3730204/ /pubmed/23872706 http://dx.doi.org/10.1038/bcj.2013.26 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Review Braggio, E Egan, J B Fonseca, R Stewart, A K Lessons from next-generation sequencing analysis in hematological malignancies |
title | Lessons from next-generation sequencing analysis in hematological malignancies |
title_full | Lessons from next-generation sequencing analysis in hematological malignancies |
title_fullStr | Lessons from next-generation sequencing analysis in hematological malignancies |
title_full_unstemmed | Lessons from next-generation sequencing analysis in hematological malignancies |
title_short | Lessons from next-generation sequencing analysis in hematological malignancies |
title_sort | lessons from next-generation sequencing analysis in hematological malignancies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730204/ https://www.ncbi.nlm.nih.gov/pubmed/23872706 http://dx.doi.org/10.1038/bcj.2013.26 |
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