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Lessons from next-generation sequencing analysis in hematological malignancies

Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention...

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Detalles Bibliográficos
Autores principales: Braggio, E, Egan, J B, Fonseca, R, Stewart, A K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730204/
https://www.ncbi.nlm.nih.gov/pubmed/23872706
http://dx.doi.org/10.1038/bcj.2013.26
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author Braggio, E
Egan, J B
Fonseca, R
Stewart, A K
author_facet Braggio, E
Egan, J B
Fonseca, R
Stewart, A K
author_sort Braggio, E
collection PubMed
description Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis.
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spelling pubmed-37302042013-08-01 Lessons from next-generation sequencing analysis in hematological malignancies Braggio, E Egan, J B Fonseca, R Stewart, A K Blood Cancer J Review Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis. Nature Publishing Group 2013-07 2013-07-19 /pmc/articles/PMC3730204/ /pubmed/23872706 http://dx.doi.org/10.1038/bcj.2013.26 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Braggio, E
Egan, J B
Fonseca, R
Stewart, A K
Lessons from next-generation sequencing analysis in hematological malignancies
title Lessons from next-generation sequencing analysis in hematological malignancies
title_full Lessons from next-generation sequencing analysis in hematological malignancies
title_fullStr Lessons from next-generation sequencing analysis in hematological malignancies
title_full_unstemmed Lessons from next-generation sequencing analysis in hematological malignancies
title_short Lessons from next-generation sequencing analysis in hematological malignancies
title_sort lessons from next-generation sequencing analysis in hematological malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730204/
https://www.ncbi.nlm.nih.gov/pubmed/23872706
http://dx.doi.org/10.1038/bcj.2013.26
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