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Structure of the human Parkin ligase domain in an autoinhibited state
Mutations in the protein Parkin are associated with Parkinson’s disease (PD), the second most common neurodegenerative disease in men. Parkin is an E3 ubiquitin (Ub) ligase of the structurally uncharacterized RING-in-between-RING(IBR)-RING (RBR) family, which, in an HECT-like fashion, forms a cataly...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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European Molecular Biology Organization
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730226/ https://www.ncbi.nlm.nih.gov/pubmed/23727886 http://dx.doi.org/10.1038/emboj.2013.125 |