Threshold-controlled ubiquitination of the EGFR directs receptor fate

How the cell converts graded signals into threshold-activated responses is a question of great biological relevance. Here, we uncover a nonlinear modality of epidermal growth factor receptor (EGFR)-activated signal transduction, by demonstrating that the ubiquitination of the EGFR at the PM is thres...

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Detalles Bibliográficos
Autores principales: Sigismund, Sara, Algisi, Veronica, Nappo, Gilda, Conte, Alexia, Pascolutti, Roberta, Cuomo, Alessandro, Bonaldi, Tiziana, Argenzio, Elisabetta, Verhoef, Lisette G G C, Maspero, Elena, Bianchi, Fabrizio, Capuani, Fabrizio, Ciliberto, Andrea, Polo, Simona, Di Fiore, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730230/
https://www.ncbi.nlm.nih.gov/pubmed/23799367
http://dx.doi.org/10.1038/emboj.2013.149

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