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Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results

Liposarcoma is one of the most common adult soft tissue sarcomas an consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment o...

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Autores principales: Tseng, William W., Somaiah, Neeta, Lazar, Alexander J., Lev, Dina C., Pollock, Raphael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730323/
https://www.ncbi.nlm.nih.gov/pubmed/24216990
http://dx.doi.org/10.3390/cancers5020529
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author Tseng, William W.
Somaiah, Neeta
Lazar, Alexander J.
Lev, Dina C.
Pollock, Raphael E.
author_facet Tseng, William W.
Somaiah, Neeta
Lazar, Alexander J.
Lev, Dina C.
Pollock, Raphael E.
author_sort Tseng, William W.
collection PubMed
description Liposarcoma is one of the most common adult soft tissue sarcomas an consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment options are currently limited. In the past decade, a better understanding of the distinct genetic and molecular aberrations for each of the three histologic subtypes has led to the development of several novel systemic therapies. Data from phase I and early phase II clinical trials have been reported. Despite challenges with conducting clinical trials in liposarcoma, preliminary results for several of these novel, biology-driven therapies are encouraging.
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spelling pubmed-37303232013-08-05 Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results Tseng, William W. Somaiah, Neeta Lazar, Alexander J. Lev, Dina C. Pollock, Raphael E. Cancers (Basel) Review Liposarcoma is one of the most common adult soft tissue sarcomas an consists of three histologic subtypes (well and dedifferentiated, myxoid/round cell, and pleomorphic). Surgery is the mainstay of treatment for localized disease; however for unresectable or metastatic disease, effective treatment options are currently limited. In the past decade, a better understanding of the distinct genetic and molecular aberrations for each of the three histologic subtypes has led to the development of several novel systemic therapies. Data from phase I and early phase II clinical trials have been reported. Despite challenges with conducting clinical trials in liposarcoma, preliminary results for several of these novel, biology-driven therapies are encouraging. MDPI 2013-05-10 /pmc/articles/PMC3730323/ /pubmed/24216990 http://dx.doi.org/10.3390/cancers5020529 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Tseng, William W.
Somaiah, Neeta
Lazar, Alexander J.
Lev, Dina C.
Pollock, Raphael E.
Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results
title Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results
title_full Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results
title_fullStr Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results
title_full_unstemmed Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results
title_short Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results
title_sort novel systemic therapies in advanced liposarcoma: a review of recent clinical trial results
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730323/
https://www.ncbi.nlm.nih.gov/pubmed/24216990
http://dx.doi.org/10.3390/cancers5020529
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