Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

We have recently shown that the crosstalk between mild endoplasmic reticulum (ER) stress and low concentrations of the pro-inflammatory cytokine interleukin (IL)-1β exacerbates beta cell inflammatory responses via the IRE1α/XBP1 pathway. We presently investigated whether mild ER stress also sensitiz...

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Detalles Bibliográficos
Autores principales: Miani, M, Barthson, J, Colli, M L, Brozzi, F, Cnop, M, Eizirik, D L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730410/
https://www.ncbi.nlm.nih.gov/pubmed/23828564
http://dx.doi.org/10.1038/cddis.2013.236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730410/
https://www.ncbi.nlm.nih.gov/pubmed/23828564
http://dx.doi.org/10.1038/cddis.2013.236

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